Results 231 to 240 of about 286,454 (285)

The nicotinamide hypothesis revisited-plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione. [PDF]

FEBS Lett
Berglund T, Ohlsson AB.
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

A multimodal radiomics model to predict disease-free survival in resected non-small cell lung cancer: integrating clinicopathology, dual-energy CT, and deep learning features. [PDF]

J Thorac Dis
Zhao W, Li T, Zhou X, Fan W, Wang Y, Zhou H, Li S, Wang J, Gu Y, Xie Z, Su F.   +10 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Dual-energy CT for distinguishing between T3 and T4 stages of locally advanced nasopharyngeal carcinoma. [PDF]

Quant Imaging Med Surg
Li L, Yang X, Qin Y, Liang J, Jiang L, Kang M, Chen L, Zeng Z, Jiang M, Chen BT.   +9 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Ivermectin attenuates nicotine-induced reward-like behaviors in mice. [PDF]

Biomol Biomed
Demirel ME, Ekici A, Yunusoğlu O.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Niclosamide nanoparticles enhance pancreatic cancer sensitivity to gemcitabine via HIF-1α inhibition. [PDF]

iScience
Nethi SK, Gunda V, Natesh NS, White BM, Mullis AS, Narasimhan B, Batra SK, Mallapragada SK, Rachagani S.   +8 more
europepmc   +1 more source

Análisis de la Aplicación de la NIC 41 en las Florícolas de Tabacundo Durante el Año 2024

Ecuador es uno de los principales exportadores de flores a nivel mundial, destacando por su calidad y variedad. Las empresas florícolas operan con un alto grado de tecnificación y están sujetas a normativas internacionales, especialmente si exportan a mercados internacionales.
openaire   +1 more source