Results 231 to 240 of about 60,125,365 (283)

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition-Associated Toxicity. [PDF]

ACS Med Chem Lett
Jiang H, Macorano A, Xing E, Jedoui M, Mohammed S, Lee V, Cheng J, McDonough L, Cheng X, Ye J, Li PK.   +10 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Pretreatment dual-energy CT versus diffusion-weighted imaging for predicting pathologic complete response to neoadjuvant chemotherapy in breast cancer. [PDF]

BMC Med Imaging
Cao Y, Cheng Y, Huang Y, Gong X, Li T, Chen H, Du L, Shi J, Zeng X, Yin T, Wang X, Zhang J.   +11 more
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Multicenter ex vivo evaluation of an α-mannosidase-targeted fluorescent probe for intraoperative margin assessment in breast cancer. [PDF]

Sci Rep
Ueo H, Ueo H, Doi T, Yamaguchi M, Akashi-Tanaka S, Takamaru T, Tsuda H, Moriya T, Yamaguchi R, Kozuka Y, Sasaki T, Gamachi A, Kai Y, Kubota Y, Kunii S, Nagamori Y, Fujita K, Urano Y, Ando Y, Mimori K, Masuda T.   +20 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Short-Term Effectiveness of a Psychotherapeutic Intervention Model in Nursing for Ineffective Coping in GAD Outpatients: A Small-Sample Randomized Controlled Trial. [PDF]

Alpha Psychiatry
Aşkan T, Özkan B, Kamış GZ, Uğurlu M.   +3 more
europepmc   +1 more source

Análisis de la Aplicación de la NIC 41 en las Florícolas de Tabacundo Durante el Año 2024

Ecuador es uno de los principales exportadores de flores a nivel mundial, destacando por su calidad y variedad. Las empresas florícolas operan con un alto grado de tecnificación y están sujetas a normativas internacionales, especialmente si exportan a mercados internacionales.
openaire   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Long-read RNA-seq maps the isoform landscape of the trigeminal ganglion in an allergic rhinitis mouse model. [PDF]

BMC Genomics
Han Z, Yu B, Shen M, Tang Z, Li X, Wang M, Li F, Cao X.   +7 more
europepmc   +1 more source