Nicardipine for treating severe antepartum hypertension during pregnancy: Nine years of experience in more than 800 women [PDF]
Acta Obstetricia et Gynecologica Scandinavica, 2022 Introduction Women with severe hypertension during pregnancy require prompt stabilization with a combination of magnesium sulfate and rapidly acting intravenously administered antihypertensives.
Sebastiaan W. Nij Bijvank +6 more
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Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications for neuroprotection. [PDF]
PLoS ONE, 2014 BACKGROUND/OBJECTIVE: Nicardipine is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.
Bor-Ren Huang +12 more
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Oral nifedipine and phytosterol, intravenous nicardipine, and oral nifedipine only: Three-arm, retrospective, cohort study for management of severe preeclampsia [PDF]
Open Life Sciences, 2023 The treatment of preeclampsia is delivering women and extracting the placenta, but the Chinese Society of Obstetrics and Gynecology guidelines do not recommend the delivery of babies without severe features.
Ma Shanduo +4 more
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Evaluation the inhibitory effect of nicardipine on the metabolism of quetiapine [PDF]
Frontiers in PharmacologyThe aim of this study was to investigate the impact of calcium channel blockers (CCBs) and antihypertensive traditional Chinese medicine (TCM) on the metabolism of quetiapine. In vitro, two incubation systems of rat liver microsomes (RLM) and human liver
Jinzhao Yang +5 more
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Differential Preincubation Effects of Nicardipine on OATP1B1- and OATP1B3-Mediated Transport in the Presence and Absence of Protein: Implications in Assessing OATP1B1- and OATP1B3-Mediated Drug–Drug Interactions [PDF]
Pharmaceutics, 2023 Impaired transport activity of hepatic OATP1B1 and OATP1B3 due to drug–drug interactions (DDIs) often leads to increased systemic exposure to substrate drugs (e.g., lipid-lowering statins).
Ruhul Kayesh +3 more
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Spectrophotometric determination of nicradipine and isradipine in pharmaceutical formulations [PDF]
Chemical Industry and Chemical Engineering Quarterly, 2009 A sensitive spectrophotometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine and isradipine either in pure form or in pharmaceutical preparations.
S. M. Al-Ghannam, A. M. Al-Olyan
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Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial Ischemia/Reperfusion Injury [PDF]
Anesthesiology Research and Practice, 2011 The aim of this experiment was to establish whether verapamil, nicardipine, and nitroglycerin have (1) infarct size-limiting effects and (2) antiarrhythmic effects in in vivo rabbit hearts during ischemia/reperfusion.
Hitoshi Yui +6 more
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The protective role of nicardipine in dextran sulfate sodium-induced colitis in mice: Modulating inflammation and apoptosis [PDF]
Toxicology ReportsUlcerative colitis (UC) is a chronic inflammatory bowel disease associated with persistent inflammation, oxidative stress, and epithelial apoptosis. Nicardipine, a dihydropyridine calcium channel blocker, exhibits anti-inflammatory and anti-apoptotic ...
Ali M. Al-Joda, Munaf H. Zalzala
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Low-dose nicardipine during cardiopulmonary bypass improves carotid hemodynamics in CABG patients: a randomized controlled trial [PDF]
Journal of Cardiothoracic SurgeryBackground Postoperative cognitive dysfunction (POCD) is a common complication of coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB), largely associated with cerebral hemodynamic disturbances.
Duanqi Zhu +6 more
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Comparison of nicardipine versus labetalol for time to alteplase administration in acute ischemic stroke [PDF]
Frontiers in NeurologyBackgroundThough the acute management of hypertension in patients with ischemic stroke has been associated with prolonged time to alteplase administration, it is unclear whether the choice of antihypertensive agent also influences this outcome.
Alex Huang +3 more
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