Results 61 to 70 of about 15,118 (218)

Intracerebral Hemorrhage: Advances, Knowledge Gaps, and Future Directions

open access: yesMedComm, Volume 6, Issue 11, November 2025.
This review provides a comprehensive synthesis of current research on the epidemiology, pathophysiological mechanisms, imaging characteristics, treatment delays, clinical management strategies, neural repair, and prognostic prediction of intracerebral hemorrhage (ICH).
Tao Liu   +6 more
wiley   +1 more source

High-performance liquid chromatographic method for the determination of nicardipine in pure, pharmaceutical preparations and plasma and its application to pharmacokinetics in humans

open access: yesOrbital: The Electronic Journal of Chemistry, 2008
A simple, sensitive and reproducible reversed-phase liquid chromatographic method has been developed and validated for the determination of nicardipine hydrochloride (NC) in pure, pharmaceutical preparations, human plasma and the study of the ...
Sheikha Mohammed Al-Ghannam   +1 more
doaj   +3 more sources

Comparison of Oral Nicardipine and Intravenous Magnesium Sulfate for Preterm Labor Pain Management [PDF]

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2007
Background and objectives 2% of all pregnancies terminate before 32 weeks and 12.5% of them before 37 weeks of gestation. Medical treatment by contraction inhibitors is the most common strategy for management of preterm labor pain.
M. Ghasemi, F. Aghaie Zadah, M. Movahedi
doaj   +2 more sources

Systems Pharmacology [PDF]

open access: yes, 2008
The slides are from a presentation given by Professor Ravi Iyengar from Mount Sinai School of Medicine at the Drug Forum Meeting #9 that took place in Washington, DC on February 20-21, 2008.
Ravi Iyengar
core   +2 more sources

Peripartum Management and Labor Stage Duration in Hypertensive Disorders in Pregnancy: A Retrospective Study in a Single Center

open access: yesThe Journal of Clinical Hypertension, Volume 27, Issue 11, November 2025.
ABSTRACT Hypertensive disorders in pregnancy (HDP) are a major cause of maternal and perinatal morbidity and mortality. The impact of HDP on labor stage duration and maternal and neonatal outcomes in nulliparous women remains unclear. To assess labor stage duration and maternal and neonatal outcomes in nulliparous women with HDP. A retrospective cohort
Hao Zhu   +4 more
wiley   +1 more source

Acute Vasoreactivity Testing With Nicardipine in Patients With Pulmonary Arterial Hypertension

open access: yesJournal of Pharmacological Sciences, 2012
Acute vasoreactivity testing for patients with pulmonary arterial hypertension (PAH) has been reported to be useful to identify patients with sustained beneficial response to oral calcium-channel blockers (CCBs), but there is a risk of exacerbation ...
Yukihiro Saito   +15 more
doaj   +1 more source

Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]

open access: yes, 2016
BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois   +10 more
core   +3 more sources

Antihypertensive therapy for pregnancy hypertension and implications for fetal and neonatal heart rate monitoring: A systematic review of randomized trials and observational studies

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 10, Page 1822-1837, October 2025.
Trials are mostly reassuring regarding antihypertensive effects on fetal (FHR) or neonatal heart rate (neoHR), but observational studies raise concerns about beta‐blockers, particularly the alpha/beta‐blocker labetalol. Clinicians should ascribe adverse fetal or neonatal heart rate effects to evolving underlying placental dysfunction or newborn illness,
Akalya Ganeshamoorthy   +9 more
wiley   +1 more source

Prognostic significance of short-term blood pressure variability in acute stroke [PDF]

open access: yes, 2015
Background and Purpose— Blood pressure variability (BPV) may be an important prognostic factor acutely after stroke. This review investigated the existing evidence for the effect of BPV on outcome after stroke, also considering ...
Manning, Lisa S.   +3 more
core   +1 more source

Efficacy and Safety of a Generic Clevidipine in Hypertensive Urgencies and Non‐Fulminant Hypertensive Emergencies: A Phase III, Multicenter, Randomized, Double‐Blind, Positive Drug Parallel‐Controlled Study

open access: yesThe Journal of Clinical Hypertension, Volume 27, Issue 10, October 2025.
Abstract Hypertensive crises require rapid blood pressure control to prevent stroke and myocardial injury. Despite Cleviprex's efficacy, its high cost limits accessibility in China. This Phase III, multicenter, randomized, double‐blind study evaluated the efficacy and safety of a generic clevidipine (China's first injectable generic clevidipine ...
Xiaoning Han   +32 more
wiley   +1 more source

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