Results 91 to 100 of about 1,623,845 (286)

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs.

Advanced Science, EarlyView.
Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress‐response genes like ATF4, rendering cells resistant to chemotherapy and apoptosis. These tumors depend on serine and cysteine from surrounding cancer‐associated fibroblasts (CAFs), which shift to produce serine by curbing collagen ...
Sauyeun Shin, Mehdi Liauzun, Jacobo Solorzano, Morgane Le Bras, Christine Jean, Benjamin Fourneaux, Margaux Dore, Lea Fevrier, Ismahane Belhabib, Alexia Brunel, Cindy Neuzillet, Marion Larroque, Carine Joffre, Stephane Rocchi, Nicolas Fraunhoffer, Aurelie Perraud, Muriel Mathonnet, Vera Pancaldi, Laetitia Linares, Juan Iovanna, Nelson Dusetti, Ola Larsson, Remy Nicolle, Stephane Pyronnet, Corinne Bousquet, Yvan Martineau   +25 more
wiley   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Cation–Anion Synergy Enables Uniform and Stable SAMs for High‐Efficiency Perovskite/TOPCon Tandem Solar Cells

Advanced Science, EarlyView.
A cation‐anion synergistic strategy is developed to enhance self‐assembled monolayer (SAM) adsorption using guanidinium thiocyanate (GuaSCN). Guanidinium (Gua⁺) suppresses micelle aggregation, while thiocyanate (SCN−) promotes phosphonic acid deprotonation and strengthens ionic bonding to the substrate.
Haofan Ma, Xin Li, Huan Li, Jianmin Guan, Luyao Zheng, Jun Wu, Ziyu He, Yunyun Yu, Jungan Wang, Jie Yang, Xinyu Zhang, Meili Zhang, Yuheng Zeng, Menglei Xu, Zhiqin Ying, Xi Yang, Jichun Ye   +16 more
wiley   +1 more source

Regularity of some invariant distributions on nice symmetric pairs

, 2014
J.~Sekiguchi determined the semisimple symmetric pairs (g,h), called nice symmetric pairs, on which there is no non-zero invariant eigendistribution with singular support.
Harinck, Pascale
core   +1 more source

Ion Crowding Effect in Unilaterally Downsized Perovskite Memristors

Advanced Science, EarlyView.
The downscaling of perovskite memristors incorporating monocrystalline nanoplates is accompanied by an ion crowding effect, which greatly enhances the local electric field in the vicinity of electrode. The highly controlled crowding of anions and vacancies results in anisotropic switching characteristics as well as unique morphology modification ...
Conghui Tan, Meiqi An, Weili Liu, Haotian Wang, Shuai Yang, Jing Li, Jianliang Li, Yingmin Luo, Chao Wang, Jiao Xu, Yaodan Chi, Yiming Yang   +11 more
wiley   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Large‐Aperture Polarization‐Independent Broadband Achromatic All‐Dielectric Metalens for Terahertz Focusing

Advanced Science, EarlyView.
A large‐aperture, high focusing efficiency and polarization‐independent THz single‐layer achromatic metalens is reported via discrete multi‐wavelength achromatic design and global optimization algorithm. The fabricated metalens exhibits a largest diameter of 2.21 cm, excellent achromatic performance, extremely high average focusing efficiency (> 46 ...
Xiaoqiang Jiang, Xu Chen, Zechuan Bin, Fu Tang, Min Hu, Manman Li, Baoli Yao   +6 more
wiley   +1 more source

R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 18

Journal of Comparative Effectiveness Research
In this update, we discuss recent publications examining the use of real-world data as a measure of treatment effectiveness in submissions to the National Institute of Health and Care Excellence, the results of a pilot study from the Coalition to ...
Paul Arora, Sreeram V Ramagopalan
doaj   +1 more source

Particle Image Velocimetry in Concentrated Suspensions: Application to Local Rheometry

Applied Rheology, 2011
This paper presents an experimental facility that allows simultaneous viscosimetric and Particle Image Velocimetry measurements on concentrated suspensions in a wide-gap Couette rheometer.
Blanc Frédéric, Peters François, Lemaire Elisabeth   +2 more
doaj   +1 more source

NICE wobbles [PDF]

Journal of the Royal Society of Medicine, 2009
Alan, Maynard, Karen, Bloor
openaire   +2 more sources