Results 61 to 70 of about 1,062,757 (298)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Differential use of nest materials and niche space among avian species within a single ecological community

Ecology and Evolution
Differential use of resources among bird species has been examined extensively in diet and nesting sites, but few studies have assessed this regarding avian nest materials.
Michael E. Akresh, David Mandell, Peter P. Grima, David I. King, Kathryn Lauer   +4 more
doaj   +1 more source

Autophagy regulated by the HIF/REDD1/mTORC1 signaling is progressively increased during erythroid differentiation under hypoxia

Frontiers in Cell and Developmental Biology, 2022
For hematopoietic stem and progenitor cells (HSPCs), hypoxia is a specific microenvironment known as the hypoxic niche. How hypoxia regulates erythroid differentiation of HSPCs remains unclear.
Jian Li, Cheng Quan, Yun-Ling He, Yan Cao, Ying Chen, Yu-Fei Wang, Li-Ying Wu   +6 more
doaj   +1 more source

Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. [PDF]

, 2005
Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric divisions.
Luciano Conti, Thorsten Gorba (59561), Mauro Toselli, Biella, G, Sanzone Sveva, Toselli, M, Austin Smith, Reitano Erika, Reitano, E, T. Gorba, Smith Austin, Steven M Pollard, E. Reitano, Sveva Sanzone (59566), BIELLA, GERARDO ROSARIO, Smith A., Reitano E, Gorba T, Ying Ql, Ying Qi-Long, Conti, L, Conti L, Sun Y, Sanzone, S, L. Conti, S. Sanzone, Toselli Mauro, Steven M Pollard (59560), Qi-Long Ying (59567), Q. L. Ying, Cattaneo Elena, Pollard, S M, Luciano Conti (59559), Y. R. Sun, Pollard Sm, Cattaneo E, Sun, Y R, Sveva Sanzone, Smith, A, Erika Reitano, Pollard Steven M, Yirui Sun, TOSELLI, MAURO GIUSEPPE, Thorsten Gorba, Ying, Q L, Yirui Sun (59565), Ying, QL, Conti Luciano, Gerardo Biella, Sun Yirui, Elena Cattaneo, E. Cattaneo, Mauro Toselli (59563), Austin Smith (59569), Qi-Long Ying, Biella Gerardo, Erika Reitano (59562), Pollard, SM, Cattaneo, E, Sanzone S, G. Biella, Gerardo Biella (59564), Gorba Thorsten, Gorba, T, A. Smith, Elena Cattaneo (59568), Sun, Y, S. M. Pollard, M. Toselli   +68 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation

Stem Cell Reports, 2018
Summary: The in vivo niche and basic cellular properties of nephron progenitors are poorly described. Here we studied the cellular organization and function of the MAPK/ERK pathway in nephron progenitors.
Anneliis Ihermann-Hella, Tsuyoshi Hirashima, Jussi Kupari, Kristen Kurtzeborn, Hao Li, Hyuk Nam Kwon, Cristina Cebrian, Abdul Soofi, Arvydas Dapkunas, Ilkka Miinalainen, Gregory R. Dressler, Michiyuki Matsuda, Satu Kuure   +12 more
doaj   +1 more source

Niche Differentiation among Sympatric Australian Dasyurid Carnivores [PDF]

Journal of Mammalogy, 2000
Niche differentiation occurred on 3 dimensions in a size-structured guild of marsupial carnivores (Marsupialia: Dasyuridae) that included the Tasmanian devil (Sarcophilus laniarius), spotted-tailed quoll (Dasyurus maculatus), and eastern quoll (D. viverrinus).
Menna E. Jones, Leon A. Barmuta
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Designing stem cell niches for differentiation and self-renewal [PDF]

Journal of The Royal Society Interface, 2018
Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in contact with their specialized microenvironment, termed thestem cell niche.
Donnelly, Hannah, Salmeron-Sanchez, Manuel, Dalby, Matthew J.   +2 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source