Results 81 to 90 of about 1,062,757 (298)
npj Clean Water, 2022 Filamentous cyanobacteria have substantial niche overlap, and the causal mechanism behind their succession remains unclear. This has practical significance since several filamentous genera are the main producers of the musty odorant 2-methylisoborneol ...
Ming Su +10 more
doaj +1 more source
Dynamic niches in the origination and differentiation of haematopoietic stem cells [PDF]
Nature Reviews Molecular Cell Biology, 2011 Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate all mature blood cells. HSC function is tightly controlled to maintain haematopoietic homeostasis, and this regulation relies on specialized cells and factors that constitute the haematopoietic 'niche', or microenvironment.
Leo D, Wang, Amy J, Wagers
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
eLife, 2020 Metabolites are major biological parameters sensed by many cell types in vivo, whether they function as signaling mediators of SC and niche cross talk to regulate tissue regeneration is largely unknown.
Zhiwei Lu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Ecology and EvolutionClosely related species coexisting in the same habitat often undergo niche differentiation or morphological adaptations to reduce interspecific competition and secure sufficient resources, particularly when their ecological niches overlap.
Jiawei Fu +7 more
doaj +1 more source
Niche diversification of Sphagnum in Bolivia [PDF]
, 1997 Niche breadth values of Sphagnum species in the páramo and cloud forests of Bolivia are similar to those reported for Sphagnum-dominated peatlands in North America, but niche overlap values are higher for Sphagnum species in Bolivia. The pH, conductivity,
McQueen, Cyrus B.
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source