Results 111 to 120 of about 106,852 (270)

METTL14 Regulates Myocardial Infarction Progression via m6A‐Dependent Modulation of OTUD1‐Mediated Deubiquitination of DUSP6

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial infarction (MI) is the most severe clinical manifestation of coronary artery diseases (CVD) and serves as a critical driver of sudden cardiac death and heart failure (HF). Its pathophysiology begins with the abrupt cessation of coronary blood flow, leading to severe ischemia and subsequent cardiomyocyte necrosis. This study aimed to
Cheng‐Cheng Wei   +2 more
wiley   +1 more source

The IceShark, an effective method for sampling plankton under sea ice

open access: yesLimnology and Oceanography: Methods, EarlyView.
Abstract Seasonal sea ice plays a crucial role in shaping coastal ecosystem dynamics throughout the circumpolar region. Of particular interest to oceanographers is the ice‐ocean interface which functions as a multidimensional habitat, supporting both sympagic algae and pelagic phytoplankton in the under‐ice surface waters.
Eleanor A. Barry   +4 more
wiley   +1 more source

Leatherneck: A Borrowed Nickname

open access: yesNames, 1965
Albert F. Moe
doaj   +1 more source

No App, No Entry: Conceptualizing Digital Technology Captivity in Service Access

open access: yesPsychology &Marketing, EarlyView.
ABSTRACT We introduce Digital Technology Captivity (DTC), a form of consumer vulnerability that arises when digital technologies become the mandatory gateway to essential services. When access is tied to systems that feel unfamiliar, complex, or intimidating—and when preferred alternatives are limited—consumers may experience heightened vulnerability ...
Carolyn Wilson‐Nash   +4 more
wiley   +1 more source

Polymerized Pro‐Estrogen Microneedles via Two Photon Polymerization

open access: yesMacromolecular Rapid Communications, EarlyView.
Acrylic pro‐drugs of 17β‐estradiol were subjected to spatially controlled two‐photon polymerization to create bespoke microneedle geometries with potential biomedical applications for long‐term transdermal hormone delivery. ABSTRACT Two‐photon polymerization (TPP) is a powerful technique to create microscale structures with high precision, offering ...
Yang Lou   +6 more
wiley   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu   +4 more
wiley   +1 more source

Clinically Feasible White Matter Fiber Tractography in Peritumoral Zones With Cerebral Vasogenic Edema

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose In diffusion MRI, vasogenic edema manifests as a major fraction of isotropic water that dilutes the anisotropic intra‐axonal portion of the signal. Many tractography algorithms mistake vasogenic edema for the white matter boundary and terminate tracking to prevent producing spurious streamlines.
Patryk Filipiak   +6 more
wiley   +1 more source

Using U‐Nets to Predict the Effects of Head Motion on Simulated Specific Absorption Rate for Ultra‐High Field Magnetic Resonance Imaging With Parallel Transmission

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Ultrahigh‐field MRI requires careful management of the specific absorption rate (SAR), which is subject and subject‐position dependent. Within‐scan subject motion may exacerbate local SAR exposure, necessitating large safety margins to prevent SAR underestimation, which hampers imaging performance.
Katherine Anna Blanter   +4 more
wiley   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

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