Results 181 to 190 of about 8,705 (221)
Some of the next articles are maybe not open access.
Injectable pegylated niclosamide (polyethylene glycol‐modified niclosamide) for cancer therapy
Journal of Biomedical Materials Research Part A, 2019AbstractNiclosamide is an antihelminthic drug. Recent studies show that niclosamide exerts antitumor activity through inhibiting multiple signals including Wnt/β‐catenin, mTORC1, signal transducer and activator of transcription 3, NF‐κB, notch signals; however, the insolubility and poor bioavailability limits its potential clinic use, the aim of the ...
Rui, Ma +8 more
openaire +2 more sources
Niclosamide Therapy for Tapeworm Infections
Annals of Internal Medicine, 1985Excerpt Niclosamide [N-(2′-chloro-4′-nitrophenyl)-5-chlorosalicylamide] was developed at Bayer A. G.
R D, Pearson, E L, Hewlett
openaire +2 more sources
A novel molluscicidal formulation of niclosamide
Parasitology Research, 2008Snail control by molluscicides is an important strategy for schistosomiasis control in China. Currently, only one chemical molluscicide, niclosamide, which is used as 50% wettable powder of niclosamide ethanolamine salt (WPN), is commercially available for field snail control in China.
Jian-Rong, Dai +5 more
openaire +2 more sources
Pharmaceutical Cocrystals of Niclosamide
Crystal Growth & Design, 2012Niclosamide (NCL) is an anthelmintic BCS class II drug of low solubility and high permeability. Pharmaceutical cocrystals of NCL were prepared with GRAS molecules, such as caffeine (CAF), urea (URE), p-aminobenzoic acid (PABA), theophylline (THPH), nicotinamide (NCT), and isonicotinamide (INA), to improve drug solubility. Neat grinding, wet granulation,
Palash Sanphui +2 more
openaire +1 more source
Anticancer Effects of Niclosamide in Human Glioblastoma
Clinical Cancer Research, 2013Abstract Purpose: Glioblastoma is a highly malignant, invariably fatal brain tumor for which effective pharmacotherapy remains an unmet medical need. Experimental Design: Screening of a compound library of 160 synthetic and natural toxic substances identified the antihelmintic niclosamide as a previously unrecognized
Wieland, Anja +20 more
openaire +3 more sources
Kinetic study and mechanism of Niclosamide degradation
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014A spectrophotometric kinetic study of Niclosamide alkaline degradation as a function of drug concentration, alkaline concentration and temperature has been established utilizing double divisor-ratio spectra spectrophotometric method. The developed method allowed determination of Niclosamide in presence of its alkaline degradation products; namely; 2 ...
Hala E, Zaazaa +4 more
openaire +2 more sources
Niclosamide: Comprehensive Profile
2005Publisher Summary This chapter presents a comprehensive profile of niclosamide, which is synthesized industrially by chlorinating salicylic acid in chlorobenzene to yield 5‐chlorosalicylic acid (I). Single‐crystal X‐ray structures of solvated forms of niclosamide revealed distinctly different modes of inclusion for different solvents.
openaire +2 more sources
Niclosamide Treatment of Cestodiasis
The American Journal of Tropical Medicine and Hygiene, 1970Abstract Niclosamide was given to 81 patients with tapeworm infection. Forty-seven patients received adequate follow-up, and 46 were cured; 17 of these had previously shown no improvement with quinacrine. Results indicate that niclosamide is a safe, simple, and effective agent against infection with Taenia saginata, Diphyllobothrium latum, and ...
D R, Perera, K A, Western, M G, Schultz
openaire +2 more sources
Yomesan (Niclosamide) Therapy of Hymenolepis Nana Infections
The American Journal of Tropical Medicine and Hygiene, 1971Abstract Yomesan—N-(2′-chlor-4′-nitrophenyl)-5 chlorsalicylamid—was ineffective in 10 children with Hymenolepis nana infections who were treated with a single dose of 100 mg per kg of body weight. On the other hand, at least 90% of 62 children who received 40 to 80 mg per kg per day for 5 days were cured as evidenced by negative stool examinations ...
H, Most +3 more
openaire +2 more sources
Polymeric molluscicides containing niclosamide moieties
Materials Science and Engineering: C, 1996Abstract Polymeric molluscicides containing a niclosamide moiety have been prepared by the chemical reactions of the commercial resins: poly(methacrylic acid),poly(styrene sulfonic acid),poly(chloromethylstyrene), poly (vinylbenzyltrimethylammonium chloride) with niclosamide.
Ahmed Akelah, Ahmed Rehab
openaire +1 more source