Results 301 to 310 of about 142,436 (357)

Muscle-Restricted Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Knockout Partially Corrects Muscle Contractility After Spinal Cord Injury in Mice. [PDF]

Neurotrauma Rep
Toro CA, De Gasperi R, Aslan A, Johnson N, Siddiq MM, Chow C, Zhao W, Harlow L, Graham Z, Liu XH, Sadoshima J, Iyengar R, Cardozo CP.   +12 more
europepmc   +1 more source

A novel glucose beta‐hydroxybutyrate combination improves hypoglycaemia recovery and patient‐reported outcomes in type 1 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Hypoglycaemia remains a major barrier to optimal diabetes management. Current treatments based on simple sugars have limitations, including rapid glucose fluctuations and persistent neuroglycopenic symptoms. We investigated FLO23011, a novel multi‐substrate energy formulation containing glucose and beta‐hydroxybutyrate, as a superior ...
D. Russell‐Jones, V. Smout, S. Roy, G. Myers, R. Littlewood, F. Shojaee‐Moradie   +5 more
wiley   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

2-hydroxy-3-methyl anthraquinone promotes apoptosis and inhibits invasion of human hepatocellular carcinoma cells by targeting nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin-1/cellular tumor antigen p53 signaling pathway. [PDF]

J Tradit Chin Med
Shuang WU, Qiao LI, Xieying Z, Taoyuan Z.   +3 more
europepmc   +1 more source

Structure-activity relations for the nicotinamide-adenine dinucleotide-linked 20beta-hydroxysteroid oxidoreductase activity of cortisone reductase with special reference to ring B.

, 1972
White Ih, Joel Jeffrey
openalex   +1 more source

Senescent hearts from male Ts65Dn mice exhibit preserved function but altered size and nicotinamide adenine dinucleotide pathway signaling.

Am J Physiol Regul Integr Comp Physiol
Brandauer J, Receno CN, Anyaoku C, Cooke LE, Schwarzer HM, DeRuisseau KC, Cunningham CM, DeRuisseau LR.   +7 more
europepmc   +1 more source

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Nicotinamide Adenine Dinucleotide Based Therapeutics

Current Medicinal Chemistry, 2008
Nicotinamide adenine dinucleotide (NAD), generally considered a key component involved in redox reactions, has been found to participate in an increasingly diverse range of cellular processes, including signal transduction, DNA repair, and post-translational protein modifications.
CHEN L, PETRELLI, Riccardo, FELCZAK K, GAO G, BONNAC L, YU JS, BENNETT EM, PANKIEWICZ KW   +7 more
openaire   +3 more sources

Nicotinamide Adenine Dinucleotide Based Therapeutics, Update

Current Medicinal Chemistry, 2015
About 500 NAD (P)-dependent enzymes in the cell use NAD (P) as a cofactor or a substrate. This family of broadly diversified enzymes is crucial for maintaining homeostasis of all living organisms. The NAD binding domain of these enzymes is conserved and it was believed that NAD mimics would not be of therapeutic value due to lack of selectivity ...
Pankiewicz, K. W, PETRELLI, Riccardo, Singh, R, Felczak, K.   +3 more
openaire   +3 more sources

Electrochemical regeneration of nicotinamide adenine dinucleotide

Biochimica et Biophysica Acta (BBA) - General Subjects, 1975
Reduced nicotinamide adenine dinucleotide (NADH) has been characterized electrochemically by solid electrode voltammetry and controlled potential electrolysis. Photometric and enzymatic assay showed that enzymatically active nicotinamide adenine dinucleotide (NAD-+) could be regenerated electrolytically from its reduced form without the use of so ...
M, Aizawa, R W, Coughlin, M, Charles
openaire   +2 more sources