Results 241 to 250 of about 297,452 (281)

Effects of freebase/protonated nicotine concentration, liquid composition and electrical power on throat hit in direct-to-lung vaping: theory and clinical measurements. [PDF]

Tob Control
El Hourani M, Lakkis I, Ammar M, AlGemayel C, Talih S, Golshahi L, Hosseini S, Ashley D, Saleh R, Eissenberg T, Breland A, Shihadeh A.   +11 more
europepmc   +1 more source

Extinction of Nicotine and Cocaine Seeking in Rats Reveals Novel, Unique and Time-Dependent Molecular Adaptations in the Medial Prefrontal Cortex. [PDF]

Cell Mol Neurobiol
Muenstermann C, Baracz SJ, Heffernan EC, Lister NC, Waters PD, Clemens KJ.   +5 more
europepmc   +1 more source

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Nicotine Vaccines

CNS & Neurological Disorders - Drug Targets, 2011
Smoking is a global healthcare problem. Current smoking cessation rates using behavioral counseling and pharmacotherapeutic interventions have had modest success, with ∼1:5 smokers remaining abstinent long-term. Nicotine vaccines are a new class of immunotherapeutics under development.
Raafat E F, Fahim, Paul D, Kessler, Steven A, Fuller, Matthew W, Kalnik   +3 more
openaire   +2 more sources

Nicotine mydriasis

Drug and Alcohol Dependence, 1989
In mice, nicotine produces dose-dependent mydriasis following interperitoneal or intracerebroventicular administration but not after local application through the conjunctival sac. Since mydriasis is not prevented by cervical sympathectomy, it is likely to be due to central inhibition of the parasympathetic tone.
M, Rosenzweig, S, Shavit, A D, Korczyn
openaire   +2 more sources

Tobacco Smoking, Nicotine, and Nicotine and Non-Nicotine Replacement Therapies

Heart Disease, 2001
Tobacco smoking is associated with an increased risk for the development of coronary and pulmonary vascular diseases and smoking cessation will greatly reduce this risk. Nicotine replacement and nonnicotine modalities have been used alone and in combination to help in smoking cessation.
W H, Frishman, T, Ky, A, Ismail
openaire   +2 more sources

Optically pure (+)-nicotine from (.+-.)-nicotine and biological comparisons with (-)-nicotine

Journal of Medicinal Chemistry, 1979
Optically pure (+)-nicotine has been obtained from (+/-)-nicotine using a combination of d-tartaric acid and di-p-toluoyl-l-tartaric acid. As the di-d-tartrate salt, (+)-nicotine is less potent than (-)-nicotine di-l-tartrate in producing lethality in mice, on blood pressure in anesthetized rats, and in the isolated guinea-pig ileum, indicating ...
M D, Aceto, B R, Martin, I M, Uwaydah, E L, May, L S, Harris, C, Izazola-Conde, W L, Dewey, T J, Bradshaw, W C, Vincek   +8 more
openaire   +2 more sources

Nicotine-mecamylamine interactions

Clinical Pharmacology & Therapeutics, 1999
Mecamylamine blocks nicotinic cholinergic receptors and has been proposed, in combination with nicotine, as a novel therapy to aid smoking cessation. The objective of this study was to characterize the pharmacokinetic and pharmacodynamic interactions between transdermal mecamylamine and intravenous nicotine.Twelve cigarette smokers were studied while ...
S, Zevin, P, Jacob, N L, Benowitz
openaire   +2 more sources