Results 251 to 260 of about 44,965 (296)
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Nicotine metabolism variability and nicotine addiction
Nicotine & Tobacco Research, 1999Individual variation in nicotine metabolism may play a role in a person's level of smoking, as well as in the transition from initiation to maintenance of a smoking behavior pattern. Since there is a paucity of research on nicotine metabolism in youth that smoke, a brief review of salient aspects of nicotine metabolism in adults provides a basis from ...
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2018
Cigarette smoking presents with considerable health risks and induces high costs on healthcare resources. People continue to smoke cigarettes in the face of adversity because they contain nicotine, which is highly addictive. Nicotine is a stimulant that exerts its effects within the brain by acting at nicotinic acetylcholine receptors (nAChRs).
David J. Nutt, Liam J. Nestor
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Cigarette smoking presents with considerable health risks and induces high costs on healthcare resources. People continue to smoke cigarettes in the face of adversity because they contain nicotine, which is highly addictive. Nicotine is a stimulant that exerts its effects within the brain by acting at nicotinic acetylcholine receptors (nAChRs).
David J. Nutt, Liam J. Nestor
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Pharmacogenetics and Nicotine Addiction Treatment
Pharmacogenomics, 2005This review focuses on the current status of, and future directions for, pharmacogenetic research on nicotine dependence and smoking cessation treatment. Pharmacological treatment involving nicotine replacement therapy and bupropion for nicotine addiction and smoking cessation has been shown to be efficacious when provided in combination with ...
Munafo, MR +4 more
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Neuronal networks of nicotine addiction
The International Journal of Biochemistry & Cell Biology, 2010Nicotine is the main psychoactive substance present in tobacco, targeting neuronal nicotinic acetylcholine receptors. The main effects of nicotine associated with smoking are nicotinic receptor activation, desensitization, and upregulation, with the subsequent modulation of the mesocorticolimbic dopaminergic system.
Marcelo O, Ortells, Hugo R, Arias
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JAMA, 1995
Objective. —To learn how nicotine has been regarded by a major tobacco company. Data Sources. —Documents from Brown and Williamson Tobacco Corporation (BW274:225-233)
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Objective. —To learn how nicotine has been regarded by a major tobacco company. Data Sources. —Documents from Brown and Williamson Tobacco Corporation (BW274:225-233)
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Nicotinic Receptors in Addiction Pathways
Molecular Pharmacology, 2013Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that consist of pentameric combinations of α and β subunits. These receptors are widely distributed throughout the brain and are highly expressed in addiction circuitry. The role of nAChRs in regulating neuronal activity and motivated behavior is complex and varies both ...
Frances M, Leslie +2 more
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Modeling Nicotine Addiction in Rats
2011Among the human population, 15% of drug users develop a pathological drug addiction. This figure increases substantially with nicotine, whereby more than 30% of those who try smoking develop a nicotine addiction. Drug addiction is characterized by compulsive drug-seeking and drug-taking behaviors (craving), and loss of control over intake despite ...
Stephanie, Caille +3 more
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Pharmacology of Nicotine: Addiction and Therapeutics
Annual Review of Pharmacology and Toxicology, 1996Nicotine maintains tobacco addiction and has therapeutic utility to aid smoking cessation and possibly to treat other medical diseases. Nicotine acts on nicotinic cholinergic receptors, which demonstrate diversity in subunit structure, function, and distribution within the nervous system, presumably mediating the complex actions of nicotine described ...
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Hawaii medical journal, 1990
Addiction to nicotine is the most common serious condition in medicine today. This chemical dependency has produced the largest epidemic of disease in this century, an epidemic that is beginning to wane in the United States but which is accelerating in the Third World.
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Addiction to nicotine is the most common serious condition in medicine today. This chemical dependency has produced the largest epidemic of disease in this century, an epidemic that is beginning to wane in the United States but which is accelerating in the Third World.
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