Results 191 to 200 of about 329,742 (333)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

The Rewards of Nicotine: Regulation by Tissue Plasminogen Activator–Plasmin System through Protease Activated Receptor-1 [PDF]

, 2006
Taku Nagai, Mina Ito, Noritaka Nakamichi, Hiroyuki Mizoguchi, Hiroyuki Kamei, Ayumi Fukakusa, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada   +8 more
openalex   +1 more source

Cloud‐Based GWAS Platform: An Innovative Solution for Efficient Acquisition and Analysis of Genomic Data

Med Research, EarlyView.
This graphical abstract illustrates the cloud‐based GWAS platform as a hub that integrates six major multiomics domains: phenomics, neuroscience, proteomics, microbiomics, metabolomics, and nutrigenomics. The platform unifies diverse data types—including clinical phenotypes, neuroimaging, plasma proteomics, microbiome profiles, metabolic biomarkers ...
Xiaohong Ke, Kailai Li, Aimin Jiang, Yasi Zhang, Qi Wang, Zhengrui Li, Jian Zhang, András Hajd, Wenjie Shi, Ulf Kahlert, Anqi Lin, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Retinal waves in mice lacking the β2 subunit of the nicotinic acetylcholine receptor

, 2008
Chao Sun, David K. Warland, José Manuel Bértolo Ballesteros, Deborah van der List, Leo M. Chalupa   +4 more
openalex   +1 more source

Effects of chronic caffeine exposure on adenosinergic modulation of the discriminative-stimulus effects of nicotine, methamphetamine, and cocaine in rats [PDF]

, 2008
Zuzana Justinová, Sergi Ferré, Chanel Barnes, Carrie E. Wertheim, Lara A. Pappas, Steven R. Goldberg, Bernard Le Foll   +6 more
openalex   +1 more source

Levodopa Disrupts Activity Patterns and Encoding of Movement in Striatal Cholinergic Interneurons of Behaving Mice

Movement Disorders, EarlyView.
Abstract Objectives Levodopa treatment, the gold standard therapy for Parkinson's disease, can lead to levodopa‐induced dyskinesias (LIDs). Recent studies in acute brain slices have implicated the neural dynamics of striatal cholinergic interneurons (CINs) in the pathophysiology of LID, reporting that their discharge becomes more bursty in dyskinetic ...
Yara Atamna, Lior Tiroshi, Nadine Wattad, Naomi Gilin, Shelly Gilad, Noa Berkowitz, Joshua A. Goldberg   +6 more
wiley   +1 more source

The Biological and Prognostic Implications of the Nicotinic Acetylcholine Receptor α3, α5, and α7 Subunits in Oral Squamous Cell Carcinoma. [PDF]

Cancer Med
Lin CM, Lin LW, Chen TC, Ye YL, Chiang BL.   +4 more
europepmc   +1 more source

Acetylcholine Attenuates Hydrogen Peroxide-Induced Intracellular Calcium Dyshomeostasis Through Both Muscarinic and Nicotinic Receptors in Cardiomyocytes [PDF]

, 2016
Siripong Palee, Nattayaporn Apaijai, Krekwit Shinlapawittayatorn, Siriporn C. Chattipakorn, Nipon Chattipakorn   +4 more
openalex   +1 more source

Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies

Movement Disorders, EarlyView.
Abstract Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Lachlan Churchill, Anna Ignatavicius, Ajay Konuri, Jack Anderson, Natasha Taylor, Simon J.G. Lewis, Elie Matar   +6 more
wiley   +1 more source

Development of a Novel Method to Quantify Quinolinic Acid in Biological Samples. [PDF]

Int J Tryptophan Res
Tasaka M, Fujigaki H, Sugiura S, Fujigaki S, Ikuno A, Yamamoto Y, Takemura M, Kimura A, Saito K.   +8 more
europepmc   +1 more source