Results 251 to 260 of about 155,011 (286)

Nicotine mydriasis

Drug and Alcohol Dependence, 1989
In mice, nicotine produces dose-dependent mydriasis following interperitoneal or intracerebroventicular administration but not after local application through the conjunctival sac. Since mydriasis is not prevented by cervical sympathectomy, it is likely to be due to central inhibition of the parasympathetic tone.
M, Rosenzweig, S, Shavit, A D, Korczyn
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Tobacco Smoking, Nicotine, and Nicotine and Non-Nicotine Replacement Therapies

Heart Disease, 2001
Tobacco smoking is associated with an increased risk for the development of coronary and pulmonary vascular diseases and smoking cessation will greatly reduce this risk. Nicotine replacement and nonnicotine modalities have been used alone and in combination to help in smoking cessation.
W H, Frishman, T, Ky, A, Ismail
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Optically pure (+)-nicotine from (.+-.)-nicotine and biological comparisons with (-)-nicotine

Journal of Medicinal Chemistry, 1979
Optically pure (+)-nicotine has been obtained from (+/-)-nicotine using a combination of d-tartaric acid and di-p-toluoyl-l-tartaric acid. As the di-d-tartrate salt, (+)-nicotine is less potent than (-)-nicotine di-l-tartrate in producing lethality in mice, on blood pressure in anesthetized rats, and in the isolated guinea-pig ileum, indicating ...
M D, Aceto, B R, Martin, I M, Uwaydah, E L, May, L S, Harris, C, Izazola-Conde, W L, Dewey, T J, Bradshaw, W C, Vincek   +8 more
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Nicotine-mecamylamine interactions

Clinical Pharmacology & Therapeutics, 1999
Mecamylamine blocks nicotinic cholinergic receptors and has been proposed, in combination with nicotine, as a novel therapy to aid smoking cessation. The objective of this study was to characterize the pharmacokinetic and pharmacodynamic interactions between transdermal mecamylamine and intravenous nicotine.Twelve cigarette smokers were studied while ...
S, Zevin, P, Jacob, N L, Benowitz
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Nicotine issues

Psychopharmacology, 1992
This issue has covered most of the important concerns of nicotine researchers. Inevitably, there are gaps, because the selection of papers could only cover those which had been submitted or were known to be in preparation and about to be submitted. Nevertheless, these articles should serve to stimulate further discussion of and investigation into all ...
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Passive immunization against nicotine prevents nicotine alleviation of nicotine abstinence syndrome

Pharmacology Biochemistry and Behavior, 2001
Passive immunization against nicotine interferes with its locomotor and pressor effects. The current study determined whether immunization could prevent another nicotine action: the reversal of nicotine abstinence syndrome. IgG containing 4.4-5.6% nicotine-specific antibody was isolated from rabbits immunized with 3'-amino-methyl-nicotine conjugated to
D H, Malin, J R, Lake, A, Lin, M, Saldaña, L, Balch, M L, Irvin, H, Chandrasekara, C L, Alvarado, Y, Hieda, D E, Keyler, P R, Pentel, S, Ennifar, L E, Basham, R, Naso, A, Fattom   +14 more
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Nicotine regulates α7 nicotinic receptor subunit mRNA: implications for nicotine dependence

Neuroreport, 2001
Recent evidence suggests that alpha7 subunit-containing nicotinic receptors (nAChRs) within the ventral tegmental area (VTA) are involved in the processes underlying nicotine tolerance and withdrawal. The current study used in situ hybridization histochemistry with multiple radiolabelled probes to amplify mRNA signal, to examine the distribution of ...
R E, Ryan, R E, Loiacono
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Nicotine Dependence

2017
Nicotine is a psychoactive drug with effects that reinforce tobacco use despite known adverse health consequences. Nicotine dependence can be effectively treated. Family physicians are in an excellent position to promote both smoking cessation and smoking prevention.
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Nicotine, Brain Nicotinic Receptors, and Neuropsychiatric Disorders

Archives of Medical Research, 2000
Neuronal nicotinic acetylcholine receptors (nAChRs) represent a large family of ligand-gated cation channels with diverse structures and properties. In contrast to the muscular nAChRs, the physiological functions of neuronal nAChRs are not well defined to date.
S, Mihailescu, R, Drucker-Colín
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SMOKING, NICOTINE, NICOTINE REPLACEMENT, AND CARDIOVASCULAR DISEASE

American Journal of Therapeutics, 1996
Cigarette smoking is a major risk factor for the development of coronary artery disease and its complications. Nicotine is one of the major substances that contributes to the pharmacologic activity of cigarette smoke, its toxicity, as well as its addictive nature.
Anjum, Ismail, William H., Frishman, Marc, Klapholz   +2 more
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