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Passive immunization against nicotine attenuates nicotine discrimination
Life Sciences, 2002Ten rats were trained in a two lever operant chamber to press different levers after a nicotine injection (0.14 mg/kg s.c.) or a saline injection on an FR10 schedule. The rats were then injected i.p. with either 150 mg nicotine-specific IgG or the same amount of control IgG from non-immunized rabbits.
David H, Malin +10 more
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Nicotine metabolism variability and nicotine addiction
Nicotine & Tobacco Research, 1999Individual variation in nicotine metabolism may play a role in a person's level of smoking, as well as in the transition from initiation to maintenance of a smoking behavior pattern. Since there is a paucity of research on nicotine metabolism in youth that smoke, a brief review of salient aspects of nicotine metabolism in adults provides a basis from ...
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Nicotine and Non-nicotine Smoking Cessation Pharmacotherapies
Cardiology in Review, 2006Cigarette smoking remains an important risk factor for premature cardiovascular disease and its complications. There are clear benefits of cigarette smoking cessation on the rate of clinical outcomes, and in addition to behavioral therapies, various pharmacologic strategies have been developed to help achieve this goal.
William H, Frishman +3 more
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