Results 221 to 230 of about 116,303 (277)

Nicotinic acetylcholine receptors and neurodegenerative disease

Alcohol, 2001
Nicotinic acetylcholine receptor (nAChR) in the central nervous system represents a new potential therapeutic target in neurodegenerative diseases, and this is driven by new findings in the molecular biology of nicotinic ion channel. Results of epidemiological studies have revealed that the incidence of Alzheimer's disease is lower among smokers ...
S, Nakamura, T, Takahashi, H, Yamashita, H, Kawakami   +3 more
openaire   +2 more sources

Nicotinic acetylcholine receptors in the brain

The nicotinic acetylcholine receptor (nAChR) is the archetypal neurotransmitter receptor within the superfamily of pentameric ligand-gated ion channels (pLGICs). Typically, it mediates fast synaptic transmission in response to its endogenous ligand, acetylcholine, and can also intervene in slower signaling mechanisms via intracellular metabolic ...
openaire   +3 more sources

Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

Nature, 2002
Hong Wang, Man Yu, M. Ochani, C. Amella, Mahira Tanović, Seenu M. Susarla, J. Li, Haichao Wang, Huan Yang, Luis Ulloa, Y. Al-Abed, C. Czura, K. Tracey   +12 more
semanticscholar   +1 more source

Refined structure of the nicotinic acetylcholine receptor at 4A resolution.

Journal of Molecular Biology, 2005
N. Unwin
semanticscholar   +1 more source

The nicotinic acetylcholine receptor; a glycoprotein

Journal of Neurochemistry, 1975
C, Mattson, E, Heilbronn
openaire   +2 more sources

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Nature, 2008
R. Hung, J. Mckay, V. Gaborieau, P. Boffetta, M. Hashibe, D. Zaridze, A. Mukeria, N. szeszenia-Dabrowska, J. Lissowska, P. Rudnai, E. Fabiánová, D. Mates, V. Bencko, L. Foretova, V. Janout, Chu Chen, G. Goodman, J. Field, T. Liloglou, G. Xinarianos, A. Cassidy, J. McLaughlin, Geoffrey Liu, S. Narod, H. Krokan, F. Skorpen, M. B. Elvestad, K. Hveem, L. Vatten, J. Linseisen, F. Clavel-Chapelon, P. Vineis, H. Bueno-de-Mesquita, E. Lund, C. Martínez, S. Bingham, T. Rasmuson, P. Hainaut, E. Riboli, W. Ahrens, S. Benhamou, S. Benhamou, P. Lagiou, D. Trichopoulos, I. Holcatova, F. Merletti, K. Kjaerheim, A. Agudo, G. Macfarlane, R. Talamini, L. Simonato, Raymond J. Lowry, D. Conway, A. Znaor, C. Healy, D. Zélénika, A. Boland, M. Delepine, M. Foglio, D. Lechner, F. Matsuda, H. Blanché, I. Gut, S. Heath, M. Lathrop, M. Lathrop, P. Brennan   +66 more
semanticscholar   +1 more source

Nicotinic acetylcholine receptors: An overview

Biochemical Pharmacology, 1984
J O, Dolly, E A, Barnard
openaire   +2 more sources

Efficacy of Varenicline, an 42 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation A Randomized Controlled Trial

, 2006
D. Jorenby, J. Hays, N. Rigotti, S. Azoulay, E. Watsky, K. Williams, C. Billing, J. Gong, K. Reeves   +8 more
semanticscholar   +1 more source

The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation.

Neuropharmacology, 2015
M. Cecchini, J. Changeux
semanticscholar   +1 more source

Functions and Pharmacology of Α2β2 Nicotinic Acetylcholine Receptors; in and Out of the Shadow of Α4β2 Nicotinic Acetylcholine Receptors

Biochemical Pharmacology
Although α2 was the first neuronal nicotinic acetylcholine receptor (nAChR) receptor subunit to be cloned, due to its low level of expression in rodent brain, its study has largely been neglected. This study provides a comparison of the α2 and α4 structures and their functional similarities, especially in regard to the existence of low and high ...
openaire   +2 more sources