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Inhibition of nicotinic acetylcholine receptors by bicuculline
Neuropharmacology, 2001A study was made on the effects of bicuculline, the classical gamma-aminobutyric acid-A receptor antagonist, on heteromeric mouse muscle alphabetagammadelta, heteromeric neuronal rat alpha2beta4 and alpha4beta2 and homomeric human alpha7 nicotinic acetylcholine receptors (nAChRs), expressed in Xenopus oocytes.
Fabrizio Eusebi +3 more
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Toxin insights into nicotinic acetylcholine receptors
Biochemical Pharmacology, 2006Venomous species have evolved cocktails of bioactive peptides to facilitate prey capture. Given their often exquisite potency and target selectivity, venom peptides provide unique biochemical tools for probing the function of membrane proteins at the molecular level.
Dutertre, S., Lewis, R. J.
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Nicotinic Acetylcholine Receptors and Anesthetics
2003Nicotinic acetylcholine receptors (nAChRs) are a diverse group of membrane proteins found in many types of excitable tissue, including brain, autonomic ganglia, and muscle. Acetylcholine (ACh), the endogenous ligand for these receptors, binds to agonist sites on nAChRs, causing opening of an intrinsic transmembrane cation channel and depolarization of ...
Stuart A. Forman +2 more
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The paradox of nicotinic acetylcholine receptor upregulation by nicotine
Trends in Pharmacological Sciences, 1990Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
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Immunology of the Nicotinic Acetylcholine Receptor
1979The classical surface antigens of Enterobacteriaceae: 0, K, and H antigens have been studied extensively in the past and have provided a basis for the taxonomy of this family (Kauffmann, 1966, 1975). In comparison to the vast knowledge accumulated on the structure, localization, genetic determination, and biologic effects of O and K antigens (Weinbaum ...
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Protein Phosphorylation of Nicotinic Acetylcholine Receptor
Critical Reviews in Biochemistry and Molecular Biology, 1989The nicotinic acetylcholine receptor (nAcChR) is a ligand-gated ion channel found in the postsynaptic membranes of electric organs, at the neuromuscular junction, and at nicotinic cholinergic synapses of the mammalian central and peripheral nervous system.
Kathryn Miles, Richard L. Huganir
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Enzymatic carboxymethylation of the nicotinic acetylcholine receptor
Biochemical and Biophysical Research Communications, 1980Summary The enzymatic carboxymethylation of the acetylcholine receptors isolated from Torpedo california is described. The acetylcholine receptor was found to be one of the most active substrates for protein carboxymethylase. The receptor methylation is not affected by the binding of cholinergic ligand.
Yoel Kloog +3 more
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Ca2+ permeability of nicotinic acetylcholine receptors
Cell Calcium, 2004Nicotinic acetylcholine receptors (nAChRs) are expressed in muscle cells and neurons, as well as in an increasing number of other cell types. The nAChR channels are permeable to cations, including Ca(2+). Ca(2+) entry through nAChR channels has been shown to modulate several Ca(2+)-dependent cellular processes, such as neurotransmitter release ...
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen +2 more
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