Results 271 to 280 of about 78,616 (322)

α7 nicotinic acetylcholine receptor agonist attenuates allergen-induced immediate nasal response in murine model of allergic rhinitis. [PDF]

J Vet Med Sci
Yamashita S, Miura K, Matsuura A, Yamasaki N, Uda N, Ogata S, Hosomi N, Nakajima S, Kitamura N, Gotoh M, Mori A, Kaminuma O.   +11 more
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Computational Design of α-Conotoxins to Target Specific Nicotinic Acetylcholine Receptor Subtypes. [PDF]

Chemistry
Wu X, Hone AJ, Huang YH, Clark RJ, McIntosh JM, Kaas Q, Craik DJ.   +6 more
europepmc   +1 more source

SR9883 is a novel small-molecule enhancer of α4β2* nicotinic acetylcholine receptor signaling that decreases intravenous nicotine self-administration in rats. [PDF]

Front Mol Neurosci
Braunscheidel KM, Voren G, Fowler CD, Lu Q, Kuryatov A, Cameron MD, Ibañez-Tallon I, Lindstrom JM, Kamenecka TM, Kenny PJ.   +9 more
europepmc   +1 more source

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The Nicotinic Acetylcholine Receptor

1985
The acetylcholine receptor (AcChR) from Torpedo electroplax has been isolated both in its native membrane-bound state and by affinity chromatography after solubilization (see Conti-Tronconi and Raftery, 1982). Purified membrane fragments can reseal, forming closed, right-side-out vesicles, which can be used for both functional and structural studies ...
Michael A. Raftery, Susan M. J. Dunn, Rebecca D. Crawford, Bianca M. Conti-Tronconi, David S. Middlemas   +4 more
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Nicotinic Acetylcholine Receptors and Epilepsy

Current Drug Target -CNS & Neurological Disorders, 2002
The neuronal nicotinic acetylcholine receptors (nAChRs) have multiple roles in the brain: they are involved in signal transduction by fast synaptic transmission, axo-axonic transmission, and in the modulation of presynaptic transmitter release. Presynaptic nAChRs can increase the release of excitatory as well as of inhibitory transmitters, and can ...
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Nicotinic Acetylcholine Receptors

2003
Publisher Summary This chapter deals with nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels
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Nicotinic Acetylcholine Receptor Assays

Current Protocols in Pharmacology, 1999
AbstractNicotinic acetylcholine receptors (nAChRs) in peripheral tissues are localized almost exclusively to autonomic nerves and the motor end plates of striated musculature. Pharmacologic analyses of nicotinic receptor antagonist potencies can be conducted by assessing the ability of these compounds to inhibit responses elicited by preganglionic ...
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Nicotinic Acetylcholine Receptors and Imaging

Current Pharmaceutical Design, 2000
In vivo imaging techniques like positron emission tomography (PET) and single photon emission computed tomography (SPECT) offer the possibility to monitor human central nicotinic acetylcholine receptors (nAChRs) in a variety of central nervous system disorders. In the past, the only available PET radiotracer for imaging nAChRs in the human brain, [11C]-
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Steroids inhibit nicotinic acetylcholine receptors

NeuroReport, 1991
Application of progesterone to Xenopus oocytes expressing a cloned neuronal nicotinic acetylcholine (nAChR) revealed two effects. The first effect was a fully reversible reduction of the current induced by acetylcholine (ACh), its onset being nearly instantaneous. The second effect, which developed in a few hours, was an irreversible suppression of ACh-
Bertrand, Daniel, Valera, Soledad, Bertrand, Sonia, Ballivet, Marc, Rungger, Duri   +4 more
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