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Neuronal Nicotinic Acetylcholine Receptors
1996Studies of the structure and function of neuronal nicotinic acetylcholine receptors (AChRs) evolved out of studies of muscle AChRs. This review will begin with a brief summary of muscle type AChRs because they are the archetype for studies of neuronal nicotinic AChRs in particular and ligand-gated ion channels in general.
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Inhibition of nicotinic acetylcholine receptors by bicuculline
Neuropharmacology, 2001A study was made on the effects of bicuculline, the classical gamma-aminobutyric acid-A receptor antagonist, on heteromeric mouse muscle alphabetagammadelta, heteromeric neuronal rat alpha2beta4 and alpha4beta2 and homomeric human alpha7 nicotinic acetylcholine receptors (nAChRs), expressed in Xenopus oocytes.
Fabrizio Eusebi +3 more
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Nicotinic Acetylcholine Receptors and Anesthetics
2003Nicotinic acetylcholine receptors (nAChRs) are a diverse group of membrane proteins found in many types of excitable tissue, including brain, autonomic ganglia, and muscle. Acetylcholine (ACh), the endogenous ligand for these receptors, binds to agonist sites on nAChRs, causing opening of an intrinsic transmembrane cation channel and depolarization of ...
Stuart A. Forman +2 more
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Immunology of the Nicotinic Acetylcholine Receptor
1979The classical surface antigens of Enterobacteriaceae: 0, K, and H antigens have been studied extensively in the past and have provided a basis for the taxonomy of this family (Kauffmann, 1966, 1975). In comparison to the vast knowledge accumulated on the structure, localization, genetic determination, and biologic effects of O and K antigens (Weinbaum ...
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The paradox of nicotinic acetylcholine receptor upregulation by nicotine
Trends in Pharmacological Sciences, 1990Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
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Protein Phosphorylation of Nicotinic Acetylcholine Receptor
Critical Reviews in Biochemistry and Molecular Biology, 1989The nicotinic acetylcholine receptor (nAcChR) is a ligand-gated ion channel found in the postsynaptic membranes of electric organs, at the neuromuscular junction, and at nicotinic cholinergic synapses of the mammalian central and peripheral nervous system.
Kathryn Miles, Richard L. Huganir
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Ca2+ permeability of nicotinic acetylcholine receptors
Cell Calcium, 2004Nicotinic acetylcholine receptors (nAChRs) are expressed in muscle cells and neurons, as well as in an increasing number of other cell types. The nAChR channels are permeable to cations, including Ca(2+). Ca(2+) entry through nAChR channels has been shown to modulate several Ca(2+)-dependent cellular processes, such as neurotransmitter release ...
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Nicotinic Acetylcholine Receptor Modulators
2014Nicotine and its pharmacology have long been associated with schizophrenia and its epidemiology and treatment. Schizophrenics use nicotine in its major delivery form of cigarettes at a significantly higher incidence than the general population (80–90% vs.
Mazurov Anatoly A, Daniel Yohannes
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Nicotinic acetylcholine receptors: An overview
Biochemical Pharmacology, 1984Eric A. Barnard, J. Oliver Dolly
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