Results 301 to 310 of about 145,182 (364)
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The paradox of nicotinic acetylcholine receptor upregulation by nicotine
Trends in Pharmacological Sciences, 1990Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
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Immunology of the Nicotinic Acetylcholine Receptor
1979The classical surface antigens of Enterobacteriaceae: 0, K, and H antigens have been studied extensively in the past and have provided a basis for the taxonomy of this family (Kauffmann, 1966, 1975). In comparison to the vast knowledge accumulated on the structure, localization, genetic determination, and biologic effects of O and K antigens (Weinbaum ...
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Nicotinic acetylcholine receptors in the brain
The nicotinic acetylcholine receptor (nAChR) is the archetypal neurotransmitter receptor within the superfamily of pentameric ligand-gated ion channels (pLGICs). Typically, it mediates fast synaptic transmission in response to its endogenous ligand, acetylcholine, and can also intervene in slower signaling mechanisms via intracellular metabolic ...openaire +3 more sources
The Nicotinic Acetylcholine Receptor
1985The acetylcholine receptor (AcChR) from Torpedo electroplax has been isolated both in its native membrane-bound state and by affinity chromatography after solubilization (see Conti-Tronconi and Raftery, 1982). Purified membrane fragments can reseal, forming closed, right-side-out vesicles, which can be used for both functional and structural studies ...
Michael A. Raftery +4 more
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Protein Phosphorylation of Nicotinic Acetylcholine Receptor
Critical Reviews in Biochemistry and Molecular Biology, 1989The nicotinic acetylcholine receptor (nAcChR) is a ligand-gated ion channel found in the postsynaptic membranes of electric organs, at the neuromuscular junction, and at nicotinic cholinergic synapses of the mammalian central and peripheral nervous system.
R L, Huganir, K, Miles
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Enzymatic carboxymethylation of the nicotinic acetylcholine receptor
Biochemical and Biophysical Research Communications, 1980Summary The enzymatic carboxymethylation of the acetylcholine receptors isolated from Torpedo california is described. The acetylcholine receptor was found to be one of the most active substrates for protein carboxymethylase. The receptor methylation is not affected by the binding of cholinergic ligand.
Y, Kloog +3 more
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Desensitization of the nicotinic acetylcholine receptor by diisopropylfluorophosphate
Journal of Biochemical Toxicology, 1988AbstractThe interaction of diisopropylfluorophosphate (DFP) with the nicotinic acetylcholine (ACh) receptor of Torpedo electric organ was studied, using [3H]‐phencyclidine ([3H]‐PCP) as a reporter probe. Phencyclidine binds with different kinetics to resting, activated, and desensitized receptor conformations.
M E, Eldefrawi +3 more
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Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Nature, 2002Hong Wang +12 more
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Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
Journal of Molecular Biology, 2005N. Unwin
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Nicotinic acetylcholine receptors: An overview
Biochemical Pharmacology, 1984J O, Dolly, E A, Barnard
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