Results 151 to 160 of about 97,079 (192)

Bacillus Subtilis 29784 as a Feed Additive for Broilers Shifts the Intestinal Microbial Composition and Supports the Production of Hypoxanthine and Nicotinic Acid. [PDF]

Animals (Basel), 2021
Choi P, Rhayat L, Pinloche E, Devillard E, De Paepe E, Vanhaecke L, Haesebrouck F, Ducatelle R, Van Immerseel F, Goossens E.   +9 more
europepmc   +1 more source

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source

Supplementation of Nicotinic Acid and Its Derivatives Up-Regulates Cellular NAD⁺ Level Rather than Nicotinamide Derivatives in Cultured Normal Human Epidermal Keratinocytes. [PDF]

Life (Basel)
Oyama T, Yamamoto T, Kameda T, Kamiya T, Abe H, Abe T, Tanuma SI.   +6 more
europepmc   +1 more source

Chemo-enzymatic synthesis of adenine substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs. [PDF]

Bioorg Med Chem, 2021
Su P, Bretz JD, Gunaratne GS, Marchant JS, Walseth TF, Slama JT.   +5 more
europepmc   +1 more source

Transcriptional response in larvae of the generalist fruit fly Anastrepha obliqua feeding on three different tropical host plants

Entomologia Experimentalis et Applicata, EarlyView.
We investigated the molecular basis of host switching by the phytophagous West Indian fruit fly (A. obliqua). Third‐instar larvae showed differential gene expression according to host plants: red mombin, mango, and carambola. The main gene categories differentially expressed were digestion, detoxification, and gene regulators.
Sandra M. Velasco‐Cuervo, César A. Lemos‐Lucumi, Maria R. Manzano, Stephen E. Strelkov, Nelson Toro‐Perea, Leonardo Galindo‐González   +5 more
wiley   +1 more source

Nicotinic acid changes rumen fermentation and apparent nutrient digestibility by regulating rumen microbiota in Xiangzhong black cattle. [PDF]

Anim Biosci
Yang Z, Bao L, Song W, Zhao X, Liang H, Yu M, Qu M.   +6 more
europepmc   +1 more source

Macrophages and autophagy: partners in crime

The FEBS Journal, EarlyView.
Autophagy is a key regulator of macrophage function, influencing critical processes like polarization, cytokine secretion, and phagocytosis. Its impact on macrophage behavior varies across different tissues and disease contexts, where it can either promote protective responses or contribute to detrimental outcomes, depending on the physiological or ...
Alessandra Vitaliti, Alessio Reggio, Alessandro Palma   +2 more
wiley   +1 more source

An adamantane‐based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation

The FEBS Journal, EarlyView.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti, Silvio Aprile, David Cabañero, Fabio Travagin, Laura Butron, Gregorio Fernández‐Ballester, Gian Cesare Tron, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel, Ubaldina Galli   +9 more
wiley   +1 more source

Plasma acetylcholine and nicotinic acid are correlated with focused preference for photographed females in depressed males: an economic game study. [PDF]

Sci Rep, 2021
Kubo H, Setoyama D, Watabe M, Ohgidani M, Hayakawa K, Kuwano N, Sato-Kasai M, Katsuki R, Kanba S, Kang D, Kato TA.   +10 more
europepmc   +1 more source

d‐amino acids: new functional insights

The FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source