Results 131 to 140 of about 55,760 (248)

The nicotinamide hypothesis revisited-plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione. [PDF]

FEBS Lett
Berglund T, Ohlsson AB.
europepmc   +1 more source

Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners. [PDF]

Molecules, 2021
Frank NA, Széles M, Akone SH, Rasheed S, Hüttel S, Frewert S, Hamed MM, Herrmann J, Schuler SMM, Hirsch AKH, Müller R.   +10 more
europepmc   +1 more source

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle, Lluna Careaga, Stefanie Malan‐Müller, Álvaro del Río‐García, Yaiza Trueba, Leticia Gil de Biedma‐Elduayen, Nuria Morales‐Puerto, Rebeca Vidal, Åsa Wiman, Sophie Erhardt, María Dolores Gutiérrez‐López, Esther O'Shea, María Isabel Colado   +12 more
wiley   +1 more source

Nicotinic acid protects against hepatic ischemia-reperfusion injury via suppressing mitochondrial damage-induced ferroptosis. [PDF]

Liver Res
Zeng Q, Sun Y, Lei M, Liu Z, Yan X, Li R, Zheng J, Zha J, Zhang L, Guan X, Yao J.   +10 more
europepmc   +1 more source

Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. [PDF]

Exp Neurol, 2021
Sasaki Y, Zhu J, Shi Y, Gu W, Kobe B, Ve T, DiAntonio A, Milbrandt J.   +7 more
europepmc   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, EarlyView.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

CD38 mediates nicotinamide mononucleotide base exchange to yield nicotinic acid mononucleotide. [PDF]

J Biol Chem
Madawala R, Banks JL, Hancock SE, Quek LE, Turner N, Wu LE.   +5 more
europepmc   +1 more source

The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility. [PDF]

Mol Ther Methods Clin Dev, 2022
Huang J, Cui L, Natarajan M, Barone PW, Wolfrum JM, Lee YH, Rice SA, Springs SL.   +7 more
europepmc   +1 more source

Nicotinic Acid Restriction Enhances the Therapeutic Benefit of NAMPT Inhibition in Small‐Cell Lung Cancer Models

Cancer Science, EarlyView.
Dietary NA restriction converts the effect of NAMPT inhibition from cytostatic to cytotoxic in SCLC in vivo. ABSTRACT Small‐cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. We previously showed that nicotinic acid riboside (NAR) sustains NAD biosynthesis in vivo and compensates for NAMPT inhibition in SCLC models ...
Kyoji Tsurumi, Miyuki Nomura, Mai Ouchi, Shigehiro Yagishita, Naohiko Kikuchi, Taku Sato, Mami Morita, Yoji Yamashita, Kayoko Hayashi, Tomoyoshi Soga, Akinobu Hamada, Tatsuro Fukuhara, Nobuhiro Tanuma   +12 more
wiley   +1 more source

Effects of Rumen-Protected Chromium-Nicotinic Acid on Lactation Performance, Nutrient Digestion, Ruminal Fermentation, Serum Biochemical Parameters, and Antioxidant in Lactating Water Buffaloes. [PDF]

Animals (Basel)
Lin Y, Zhao R, Zhang S, Yan H, Sun J, Zhao Y, Huo W, Liu Q, Wang C, Chen L, Guo G.   +10 more
europepmc   +1 more source