Results 121 to 130 of about 21,014 (223)

Drug Discovery Targeting Nicotinic Acetylcholine Receptors for Hearing Loss. [PDF]

Int J Mol Sci
Oman J, Sapkota P, Mateen S, Schulte M, Pashikanti S.   +4 more
europepmc   +1 more source

Baclofen Modulates Neural Intrinsic Functional Connectivity in Treatment‐Seeking Individuals With Alcohol Use Disorder

Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.
In a randomized, double‐blind study of individuals with alcohol use disorder, high‐dose baclofen (75 mg/day) compared with placebo was associated with differences in resting‐state functional connectivity, with higher connectivity in reward and stress‐related regions and lower connectivity in attentional and salience networks.
Warren B. Logge, Tristan P. Hurzeler, Paul S. Haber, Laurence Mealing, Andrew J. Baillie, Kirsten C. Morley   +5 more
wiley   +1 more source

Nicotinic acetylcholine receptors in pain modulation. [PDF]

Front Pharmacol
Cheng J, Chang J, Li S.
europepmc   +1 more source

Assessing Major Adverse Liver Outcomes With Baclofen Compared to Acamprosate in Compensated Alcohol‐Associated Cirrhosis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 12, Page 1673-1684, June 2026.
We conducted a nationwide, multicenter cohort study using a target trial emulation framework to compare baclofen and acamprosate in patients with compensated alcohol‐associated cirrhosis. After matching, baclofen initiation was associated with a higher 1‐year risk of major adverse liver outcomes, driven primarily by hepatic encephalopathy, particularly
Yee Hui Yeo, Sepideh Mehravar, Ellen Choi, Ju Dong Yang, Hyun‐Seok Kim, Yun Wang, Aarshi Vipani, Hirsh D. Trivedi, Walid Ayoub, Parnian Naji, Alexander Kuo, Chun‐Ying Wu, Lorenzo Leggio, Juan Pablo Arab   +13 more
wiley   +1 more source

Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats. [PDF]

Psychopharmacology (Berl), 2018
Maggio SE, Saunders MA, Baxter TA, Nixon K, Prendergast MA, Zheng G, Crooks P, Dwoskin LP, Slack RD, Newman AH, Bell RL, Bardo MT.   +11 more
europepmc   +1 more source

Cerebrospinal Fluid and Plasma Concentrations of Atogepant in Humans

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT The aim of this study was to determine the cerebrospinal fluid (CSF) to plasma concentration ratio of atogepant. Healthy adult participants (N = 28) were enrolled into this phase 1, open‐label study and received atogepant 60 mg once daily for 8 days. Steady‐state atogepant concentrations were determined from CSF samples collected on Day 6 at 2
Ramesh R. Boinpally, Joel M. Trugman
wiley   +1 more source

β-Hydroxybutyrate attenuates bronchial smooth muscle proinflammatory cytokine production and contraction. [PDF]

Am J Physiol Cell Physiol
Fastiggi VA, Mank MM, Caporizzo MA, Poynter ME.   +3 more
europepmc   +1 more source

Kidney supportive care in Australia and New Zealand: an Australian and New Zealand Society of Nephrology (ANZSN) and Australian and New Zealand Society of Palliative Medicine (ANZSPM) guidance document

Internal Medicine Journal, Volume 56, Issue S2, Page 4-48, June 2026.
The purpose of this document is to provide a summary of the current expert opinion and recent literature for clinicians, Indigenous health workers and patient advocates interested in Kidney Supportive Care (KSC) in Australia and New Zealand. Our purpose is not to duplicate the recently released International Society of Nephrology (ISN) KSC/Conservative
Kathryn Ducharlet, Frank Brennan, Rajesh Raj, Charlotte Ogivly, Elizabeth Stallworthy, Kelly Chenlei Li, Alice Kennard, Selina Bob, Nicole Scholes‐Robertson, Riona Pais, Jenny Chen, Kirsten Hepburn, Lisa Jeffs, Ilse Berquier, Jacquelyne Hughes, Christine Sanderson, Sara Rendo, Gowri Raman, Erin Vaughan, Sarah So, Curtis Walker, Suetonia Green, Rangimarie Nadia Glavish, Mark Brown   +23 more
wiley   +1 more source

Lean Mass Gains, Cardiac Remodeling, and Muscle Oxidative Changes With High‐Dose Salbutamol During Resistance Training: A Randomized Controlled Trial

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 6, June 2026.
ABSTRACT Misuse of beta2‐agonists to promote leanness is increasingly reported among young men undertaking resistance training. However, preclinical models demonstrate adverse cardiac remodeling with high‐dose beta2‐agonist. We investigated effects of prolonged supratherapeutic treatment with salbutamol on body composition, cardiac morphology and ...
Morten Hostrup, Søren Jessen, Susanne Glasius Tischer, Anders Kalsen, Rakin Hadad, Philip Lykkebæk Bonde, Michael Kreiberg, Anders Schulze Gad, Ahmad Sajadieh, Vibeke Backer, Jens Bangsbo, Hanne Rasmusen   +11 more
wiley   +1 more source

Test–retest reliability of Doppler ultrasound‐based leg blood flow assessments during exercise in patients with chronic obstructive pulmonary disease

Experimental Physiology, Volume 111, Issue 6, Page 2987-2999, 1 June 2026.
Abstract Doppler ultrasound may be used to assess leg blood flow (Q̇leg${{\dot{Q}}_{{\mathrm{leg}}}}$), but the reliability of this method remains unexplored in patients with chronic obstructive pulmonary disease (COPD), where between‐subject variability may be larger than healthy due to peripheral vascular changes.
Milan Mohammad, Jacob P. Hartmann, Amalie B. Andersen, Helene L. Hartmeyer, Ulrik W. Iepsen, Ronan M. G. Berg   +5 more
wiley   +1 more source