Results 231 to 240 of about 40,056 (270)

7-Azaindole derivatives as potential partial nicotinic agonists

Bioorganic & Medicinal Chemistry Letters, 2008
We have investigated a series of 7-azaindoles as potential partial agonists of the alpha4beta2 nicotinic acetylcholine receptor (nAChR). Three series of 7-azaindole derivatives have been synthesized and evaluated for rat brain neuronal nicotinic receptor affinity and functional activity.
Axel R, Stoit, Arnold P, den Hartog, Harry, Mons, Sjoerd, van Schaik, Nynke, Barkhuijsen, Cees, Stroomer, Hein K A C, Coolen, Jan Hendrik, Reinders, Tiny J P, Adolfs, Martina, van der Neut, Hiskias, Keizer, Chris G, Kruse   +11 more
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The therapeutic potential of nicotine and nicotinic agonists for weight control

Expert Opinion on Investigational Drugs, 1999
Transdermal nicotine patches have been successfully introduced as a safe and powerful aid to smoking cessation; this has contributed to the rising interest in additional therapeutic applications for nicotine and synthetic nicotinic agonists. Nicotine and nicotinic agonists may have a therapeutic potential for a variety of disorders, including Alzheimer'
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Effects of nicotinic agonists on the NMDA receptor

Brain Research, 1991
The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, were able to displace [3H]dizocilpine
E, Aizenman, L H, Tang, I J, Reynolds
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ABT — 418, a Novel Nicotinic Agonist

1994
With the plethora of receptor targets evolving as the result of nicotinic acetylcholine receptor (nAChR) cloning it is possible that new molecular entities selective for subtypes of nAChRs can be developed which are potentially free of the side effect liabilities associated with (-)-nicotine.
S. P. Arneric, M. Williams, M. W. Holladay, J. T. Wasicak, D. Donnelly-Roberts, D. J. Anderson, P. Pavlik, Y. C. Martin, D. S. Garvey, J. P. Sullivan, G. Wilkie, Susan Wonnacott, S. F. Robinson, James R. Pauly, M. W. Decke, J. D. Brioni, M. J. Buckley, P. Curzon, A. B. O’Neill, D. J. B. Kim, M. Majchrzak, K. Marsh, S. Quigley, A. D. Rodrigues, R. Radek, J. J. Buccafusco, W. J. Jackson, A. V. Terry, K. C. Marsh, M. W. Decker, S. P. Amend, J. R. Pauly   +31 more
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Discriminative stimulus properties of the nicotinic agonist cytisine

Psychopharmacology, 1997
Cytisine binds with high affinity and specificity to neuronal nicotinic receptors but its physiological and behavioural effects are complex and differ from those of nicotine. The present study explores the behavioural aspects further by comparing the discriminative stimulus effects of cystisine with those of nicotine. Two groups of rats were trained to
C J, Chandler, I P, Stolerman
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Epibatidine, a novel nicotinic receptor agonist

1994
It is speculated that nicotine receptor ligands might be of therapeutic benefit for the treatment of obesity, anxiety, and memory loss. With the exception of nicotine, few selective high-affinity agents exist. (-)Epibatidine (1), isolated from Ecuadoran frogs, shows structural resemblence to (-)nicotine (2). Molecular modeling studies reveal that the N
M. Dukat, D. Dumas, M. I. Damaj, W. Glassco, E. L. May, B. R. Martin, R. A. Glennon, D. M. Wypij, T. Y. Shen, K. R. Creasy, J. Rosecrans, J. P. Sullivan, A. W. Bannon, D. Donnelly-Roberts, D. J. Anderson, M. Piattoni-Kaplan, M. Gopalakrishnan, M. W. Decker, S. P. Arneric, R. Loring, T. McHugh, X. Zhang, J. McKay   +22 more
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Nicotinic Agonists, Antagonists, and Modulators From Natural Sources

Cellular and Molecular Neurobiology, 2005
1. Acetylcholine receptors were initially defined as nicotinic or muscarinic, based on selective activation by two natural products, nicotine and muscarine. Several further nicotinic agonists have been discovered from natural sources, including cytisine, anatoxin, ferruginine, anabaseine, epibatidine, and epiquinamide.
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Nicotinic Acid Receptor Agonists

Journal of Medicinal Chemistry, 2008
P Douglas, Boatman, Jeremy G, Richman, Graeme, Semple   +2 more
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Agonist efficiency in a nicotinic receptor

Biophysical Journal, 2023
Dinesh Indurthi, Anthony Auerbach
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Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor

Neuron, 2022
Eleftherios Zarkadas, Mackenzie J Thompson, Guy Schoehn   +2 more
exaly