Results 41 to 50 of about 40,056 (270)

Nicotinic potentiation of frog retinotectal transmission in tectum layer F by α3β2, α4β2, α2β4, α6β2, or α7 acetylcholine receptor subtypes

Medicina, 2015
Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas, Vilija Kuraitė, Antanas Kuras   +2 more
doaj   +1 more source

Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. [PDF]

PLoS ONE, 2014
Three recently discovered tentacle muscles are crucial to perform patterned movements of upper tentacles of the terrestrial snail, Helix pomatia. The muscles receive central and peripheral excitatory cholinergic innervation lacking inhibitory innervation.
Tibor Kiss, Nóra Krajcs, Zsolt Pirger, László Hernádi   +3 more
doaj   +1 more source

Sulfonium Ligands of the α7 nAChR

Molecules, 2021
The α7 nicotinic acetylcholine receptor (nAChR) is an important target given its role in cognitive function as well as in the cholinergic anti-inflammatory pathway, where ligands that are effective at stabilizing desensitized states of the receptor are ...
Nicole A. Horenstein, Clare Stokes, Roger L. Papke   +2 more
doaj   +1 more source

Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine [PDF]

, 2013
Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA).
A Taly, AA Grace, AJ Yu, AO Komendantov, AR Tapper, B Buisson, B Katz, Boris Gutkin, C Lüscher, C Shelley, CP Fenster, DB Carr, E Lichtenstein, E Sher, EJ Nestler, F Marti, FE Pontieri, G Di Chiara, G Di Chiara, G Di Chiara, GL Forster, HD Mansvelder, HD Mansvelder, HR Wilson, IW Jones, J Cornwall, J Grenhoff, JA Dani, Ja Dani, JB Eaton, JE Henningfield, JE Rose, JN Reynolds, JP Changeux, JP Changeux, JP Changeux, JR Clements, JR Wooltorton, K Chergui, Karl J. Friston, KG Paradiso, LE Chavez-Noriega, M Gao, M Garzón, M Graupner, M Mameli-Engvall, M Wu, MG Lacey, Michael Graupner, MJ Christie, MR Picciotto, MR Picciotto, N Champtiaux, P Dayan, PW Kalivas, R Exley, R Giniatullin, R Klink, R Nashmi, Reinoud Maex, RL Papke, S Erhardt, S Ikemoto, S Tolu, SA Oakman, SC Steffensen, SR Grady, SR Sesack, SW Johnson, SW Johnson, TC Jhou, V David, V Gerzanich, V Gerzanich, VI Pidoplichko, WA Corrigall, X Peng, ZM Fagen, ZY Tong   +78 more
core   +6 more sources

Critical Role of CA1 Nicotinic Receptors on Memory Acquisition Deficit Under Induction of Total Sleep Deprivation and REM Sleep Deprivation

International Clinical Neuroscience Journal, 2018
Background: Sleep disorder or sleep deprivation (SD) is a common issue in today’s society. Numerous evidences show that sleep is essential for proper brain performance and cognitive processes; on the other hand, cognitive functions have a broad range ...
Bibi-Zahra Javad-Moosavi, Gholamhassan Vaezi, Mohammad Nasehi, Seyed-Ali Haeri-Rouhani, Mohammad-Reza Zarrindast   +4 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

The kynurenine pathway and the brain: challenges, controversies and promises [PDF]

, 2017
Research on the neurobiology of the kynurenine pathway has suffered years of relative obscurity because tryptophan degradation, and its involvement in both physiology and major brain diseases, was viewed almost exclusively through the lens of the well ...
Schwarcz, Robert, Stone, Trevor W.
core   +1 more source

CB2R agonist prevents nicotine induced lung fibrosis

Experimental Lung Research, 2018
Nicotine stimulates fibroblast proliferation while increasing inflammation and fibrosis of tissues. The cannabinoid receptor 1 (CB1R) is mainly located in the CNS, while cannabinoid receptor 2 (CB2R) is located in the immune cells within the body. CB2R regulates inflammatory processes and fibroblast function.We investigated the impact of CB2R agonist ...
Ewelina, Wawryk-Gawda, Katarzyna, Chłapek, Michał K, Zarobkiewicz, Marta, Lis-Sochocka, Patrycja, Chylińska-Wrzos, Anna, Boguszewska-Czubara, Mirosław A, Sławiński, Anna, Franczak, Barbara, Jodłowska-Jędrych, Grażyna, Biała   +9 more
openaire   +3 more sources

Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists [PDF]

British Journal of Pharmacology, 1999
The dose‐response parameters of recombinant mouse adult neuromuscular acetylcholine receptor channels (nAChR) activated by carbamylcholine, nicotine, muscarine and oxotremorine were measured. Rate constants for agonist association and dissociation, and channel opening and closing, were estimated from single‐channel kinetic analysis.
G, Akk, A, Auerbach
openaire   +2 more sources