Results 111 to 120 of about 143,741 (208)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures.

, 2011
International audienceNumerous high-resolution crystallographic structures of the acetylcholine binding protein (AChBP), a molluscan cholinergic protein, homologous to the extracellular domain of nicotinic acetylcholine receptors, are available.
Michael Nilges, Antoine Taly, Taly, Antoine, Colas, Claire, Corringer, Pierre-Jean, Nilges, Michael, Claire Colas, Malliavin, Thérèse, Arnaud Blondel, Joseph, Delphine, Pierre-Jean Corringer, Blondel, Arnaud, Delphine Joseph, Thérèse Malliavin   +13 more
core   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties. [PDF]

J Clin Invest, 2020
Knowland D, Gu S, Eckert WA, Dawe GB, Matta JA, Limberis J, Wickenden AD, Bhattacharya A, Bredt DS.   +8 more
europepmc   +1 more source

The dual incretin agonist tirzepatide blunts nicotine‐induced behaviours and neurochemistry in male mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Nicotine dependence remains one of the leading causes of morbidity and mortality worldwide, with high relapse rates and post‐cessation weight gain representing persistent barriers to sustained abstinence. The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) have ...
Christian E. Edvardsson, Thaynnam A. Emous, Sarah Witley, Mia Ericson, Louise Adermark, Elisabet Jerlhag   +5 more
wiley   +1 more source

Survival of COVID-19 patients requires precise immune regulation: The hypothetical immunoprotective role of nicotinic agonists. [PDF]

Med Hypotheses, 2020
Allahverdi Khani M, SalehiRad M, Darbeheshti S, Motaghinejad M.   +3 more
europepmc   +1 more source

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

Imidacloprid Alters Activity and Responses to a Visual Predator Stimulus in Aussie Bronze Jumping Spiders (Helpis minitabunda, Araneae, Salticidae)

Ethology, EarlyView.
A field‐recommended concentration of a commercial imidacloprid formulation reduced open arena activity and slowed climbing in the jumping spider Helpis minitabunda. Exposed spiders still detected a looming predator stimulus, but their responses were reduced.
Reshnu Rajan‐Sheela, Gregory I. Holwell, Anne Wignall   +2 more
wiley   +1 more source

Distribution of Nicotinic Receptors in the Human Brain: Quantitative Autoradiography Using 3H-Nicotine

, 1988
Several studies showed clearly that the mammalian central nervous system possess nicotinic receptors. Recently, using membrane receptor binding studies the regional distribution of 3H-nicotine and/or H-acetylcholine binding sites in the human brain has ...
Abdu Adem, Per-Göran Gillberg, Gillberg, P-G, Jossan, SS, Nordberg, A, Sukhwinder S. Jossan, Adem, A, Sara, V, Vicki Sara, Agneta Nordberg   +9 more
core   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source