Results 121 to 130 of about 17,562 (163)
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Discriminative stimulus properties of the nicotinic agonist cytisine
Psychopharmacology, 1997Cytisine binds with high affinity and specificity to neuronal nicotinic receptors but its physiological and behavioural effects are complex and differ from those of nicotine. The present study explores the behavioural aspects further by comparing the discriminative stimulus effects of cystisine with those of nicotine. Two groups of rats were trained to
C J, Chandler, I P, Stolerman
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NICOTINIC AGONIST MODULATION OF FELINE BRONCHOMOTOR TONE
Clinical and Experimental Pharmacology and Physiology, 1990SUMMARY1. The bronchomotor actions of three nicotinic cholinoceptor agonists were investigated in anaesthetized, mechanically ventilated cats. The agonists were administered intravenously after increasing baseline airways smooth muscle tone with an infusion of 5‐hydroxytryptamine.2.
D C, Thompson, R J, Altiere, L, Diamond
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HM74a Agonists: Will they be the New Generation of Nicotinic Acid?
Current Topics in Medicinal Chemistry, 2009The discovery of HM74a as a high affinity receptor for nicotinic acid has opened up new areas for investigation. Since its discovery, several new chemical entities have been reported as HM74a agonists. One of them, MK-0354, has been tested in phase II studies, but despite significant decreases in Free Fatty Acid levels with absence of flushing events ...
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Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.
The Journal of Pharmacology and Experimental Therapeutics, 1996The present experiments assessed the influence of nicotinic cholinergic receptors on latent inhibition (LI), which is the decrement in Pavlovian conditioning resulting from extensive preexposure to a conditioned stimulus (CS). LI was assessed within a conditioned emotional response paradigm involving three phases: preexposure [either 0 (nonpreexposed ...
J, Rochford, A P, Sen, R, Quirion
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Nicotinic Acid Receptor Agonists
Journal of Medicinal Chemistry, 2008P Douglas, Boatman +2 more
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Agonist efficiency in a nicotinic receptor
Biophysical Journal, 2023Dinesh Indurthi, Anthony Auerbach
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Selective Agonists and Antagonists of α9 Versus α7 Nicotinic Acetylcholine Receptors
ACS Chemical Neuroscience, 2022Nicole A Horenstein +2 more
exaly
Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists.
Ciba Foundation symposium, 1990Although numerous studies have demonstrated that chronic nicotine treatment often results in tolerance to this drug, the mechanisms that underlie this tolerance are not well defined. Recent evidence suggests that chronic nicotine treatment results in an up-regulation of brain nicotinic receptors, but the majority of these receptors may be desensitized ...
A C, Collins +3 more
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