Results 141 to 150 of about 143,741 (208)

Methamphetamine-like discriminative-stimulus effects of nicotinic agonists. [PDF]

J Pharmacol Exp Ther, 2014
Desai RI, Bergman J.
europepmc   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

The Effect of Carbetocin on Cardiac Repolarization: A Randomized, Placebo‐ and Positive‐Controlled QT/QTc Study in Healthy Adults

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Carbetocin is an oxytocin receptor agonist used for postpartum hemorrhage prevention. While oxytocin is known to transiently prolong the QT/QTc interval, robust QTc data for carbetocin are limited. Carbetocin is known to elevate HR, which can impact QTc analyses; thus, a dose that did not overly elevate HR was important to select.
Daniël M. Jonker, Katie Barletta, Ekaterine Bagci, Kyle Raymond, Philippe Pinton   +4 more
wiley   +1 more source

Multi‐omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells

Experimental Physiology, Volume 111, Issue 10, Page 4894-4914, 1 October 2026.
Abstract Balance and gaze rely on the rapid and accurate detection and signalling of head movements by vestibular type I and type II hair cells. Signal transduction and transmission involve several types of ion channels, which are acquired progressively during hair cell differentiation and whose identity is known only in part.
Giulia Cheli, Roberta Giunta, Francesca Stella, Eleonora Guidi, Umberto Laforenza, Mariarosa Polimeni, Giancarlo Russo, Francesca Borgo, Lazarevic Dejan, Sergio Masetto   +9 more
wiley   +1 more source

T1249 Effect of Two Novel, Selective Alpha4beta2 Nicotinic Receptor Partial Agonists On Restraint Stress-Induced Defecation in Rats

, 2009
T1249 Effect of Two Novel, Selective Alpha4beta2 Nicotinic Receptor Partial Agonists On Restraint Stress-Induced Defecation in ...
Mitsuhisa Kawai (2921448), Jeremy D Gale (13841165), John Furness (13070439), Katsuyo Ohashi-Doi (4358713)   +3 more
core  

Synthetic Approaches to Novel Pyridine and Indole Derivatives as Potential Agents for the Treatment of Neurodegenerative Disorders [PDF]

Alzheimer’s Disease (AD), Parkinson’s Disease (PD) and Lewy Body Disease (LBD) are some of the many neurodegenerative disorders associated with dementia, for which there is no ultimate cure.
Colgin, Neil
core   +1 more source

Nicotinic Acetylcholine Receptor Signaling Activates Beige Adipocytes and Mediates Systemic Metabolism. [PDF]

Diabetes
Liu S, Zhu K, Zhang W, Pan T, O'Brien M, Abe I, Dale L, Piejak J, Houssein N, Zhang B, Fein M, Kajimura S, Yung R, Xu XZS, Wu J.   +14 more
europepmc   +1 more source

Alpha-7 nicotinic agonists for cognitive deficits in neuropsychiatric disorders: A translational meta-analysis of rodent and human studies. [PDF]

Prog Neuropsychopharmacol Biol Psychiatry, 2017
Lewis AS, van Schalkwyk GI, Bloch MH.
europepmc   +1 more source

Targeted Mutations Activate Allosteric Modulation of α5-Containing Nicotinic Acetylcholine Receptors. [PDF]

ACS Chem Neurosci
Marotta CB, Lester HA, Dougherty DA.
europepmc   +1 more source

Reduced flexibility hybrids of the nicotinic agonists 1,1 dimethyl-4-acetylpiperazinium iodide and 2-(dimethylamino)methyl-5-methyl-cyclopentanone methiodide

, 1997
A series of products of hybridization of known nicotinic agonists (1-3) has been synthesized; their biological activity has been evaluated in vitro on rat cerebral cortex and on guinea pig ileum, and (for some of them) in vivo for analgesic activity ...
GUALTIERI F., VALLE G., MANETTI D., GHELARDINI C., ROMANELLI M.N., BOREA, Pier Andrea, SCAPECCHI S.   +6 more
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