Results 201 to 210 of about 91,243 (276)

Rare but relevant: MDMA and hyponatraemia

Addiction, EarlyView.
Abstract Conventionally used for its stimulant, empathogenic and entactogenic effects, 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most commonly used psychoactive drugs, specifically among young adults and in nightlife and recreational party contexts.
Maria Rita Garcia, Nelson G. M. Gomes, Diana Dias‐da‐Silva   +2 more
wiley   +1 more source

Activation of Neuronal Nicotinic Receptors Inhibits Acetylcholine Release in the Neuromuscular Junction by Increasing Ca²⁺ Flux through Ca_v1 Channels. [PDF]

Int J Mol Sci, 2021
Zhilyakov N, Arkhipov A, Malomouzh A, Samigullin D.   +3 more
europepmc   +1 more source

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

α4 nicotinic receptors on GABAergic neurons mediate a cholinergic analgesic circuit in the substantia nigra pars reticulata. [PDF]

Acta Pharmacol Sin
Han Y, Zhang JQ, Ji YW, Luan YW, Li SY, Geng HZ, Ji Y, Yin C, Liu S, Zhou CY, Xiao C.   +10 more
europepmc   +1 more source

Nicotinic Receptors in Sleep-Related Hypermotor Epilepsy: Pathophysiology and Pharmacology. [PDF]

Brain Sci, 2020
Becchetti A, Grandi LC, Colombo G, Meneghini S, Amadeo A.   +4 more
europepmc   +1 more source

Outdated tools, underestimated harm: Modernizing cannabis surveillance in a post‐legalization era

Addiction, EarlyView.
Abstract Background Canada's 2018 legalization of non‐medical cannabis was positioned as a public health initiative, intended to shift cannabis use from criminalization to regulation. Since then, cannabis access and consumption have grown significantly but the systems used to monitor cannabis‐related harms have not kept pace.
Anees Bahji
wiley   +1 more source

Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters. [PDF]

ACS Chem Neurosci
Williams BM, Steed ND, Woolley JT, Moedl AA, Nelson CA, Jones GC, Burris MD, Arias HR, Kim OH, Jang EY, Hone AJ, McIntosh JM, Yorgason JT, Steffensen SC.   +13 more
europepmc   +1 more source

Appetitive responses toward smoking‐related stimuli in abstinence‐motivated, non‐deprived individuals with chronic tobacco dependence: A multi‐methodological investigation

Addiction, EarlyView.
Abstract Background and aims Appetitive responses, such as approach biases, are thought to play a crucial role in smoking. This study aimed to compare responses toward smoking‐related stimuli with responses in control conditions (e.g. non‐approach or neutral stimuli) using a multi‐method approach. By examining associations between response measures and
Franziska Motka, Haoye Tan, Seth M. Levine, Sabine Vollstädt‐Klein, Sarah K. Danböck, Katja Bertsch, Markus H. Winkler, Charlotte E. Wittekind   +7 more
wiley   +1 more source

Continuing use of e‐cigarettes after stopping smoking and relapse: Secondary analysis of a large randomised controlled trial

Addiction, EarlyView.
Abstract Background and aims Smokers quitting successfully with the help of e‐cigarettes often continue vaping. It is not known whether this promotes or prevents relapse back to smoking. This study aimed to determine whether use of e‐cigarettes after successful smoking cessation affects the probability of relapse later on.
Peter Hajek, Dunja Przulj, Katie Myers Smith, Jinshuo Li, Peter Sasieni, Louise Ross, Hayden McRobbie, Maciej Goniewicz, Francesca Pesola   +8 more
wiley   +1 more source

Serum autoantibodies against α7-nicotinic receptors in subgroups of patients with bipolar disorder or schizophrenia: clinical features and link with peripheral inflammation. [PDF]

Transl Psychiatry
Darrau E, Jacquemet E, Pons S, Schlick L, Zouridakis M, Wu CL, Richard JR, Barau C, Le Corvoisier P, Yolken R, Tamouza R, Leboyer M, Maskos U.   +12 more
europepmc   +1 more source