Results 61 to 70 of about 57,977 (335)
Cloning and characterization of the hamster and guinea pig nicotinic acid receptors
Journal of Lipid Research, 2007 In this study, we present the identification and characterization of hamster and guinea pig nicotinic acid receptors. The hamster receptor shares ∼80–90% identity with the nucleotide and amino acid sequences of human, mouse, and rat receptors. The guinea
April Smith Torhan +3 more
doaj
Nicotine dependence and genetic variation in the nicotinic receptors [PDF]
Drug and Alcohol Dependence, 2009 Technological advances have led to the discovery of genetic variants that contribute to many illnesses including nicotine dependence. A multi-stage model of the development of nicotine dependence underlies these genetic studies, and it includes a progression through several stages of smoking behavior from never smoking to nicotine dependence. The final
openaire +3 more sources
Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity
Angewandte Chemie International Edition, EarlyView.A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt +14 more
wiley +1 more source
Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes
Pharmacological Research, 2023 Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate immune system.
Katrin Richter, Veronika Grau
doaj
Schizophrenia Research: Cognition, 2016 The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) project designed to facilitate the development of new drugs for the treatment of cognitive impairments in people with schizophrenia, identified three drug mechanisms ...
Maju Mathew Koola
doaj +1 more source
Venom-Derived Neurotoxins Targeting Nicotinic Acetylcholine Receptors
Molecules, 2021 Acetylcholine was the first neurotransmitter described. The receptors targeted by acetylcholine are found within organisms spanning different phyla and position themselves as very attractive targets for predation, as well as for defense. Venoms of snakes
Ayaulym Bekbossynova +2 more
doaj +1 more source
Nicotinic Receptor Function in Schizophrenia [PDF]
Schizophrenia Bulletin, 1996 Schizophrenia can be partially characterized by deficits in sensory processing. Biochemical, molecular, and genetic studies of one such endophenotype, the P50 auditory-evoked potential gating deficit, suggest that one of the neuronal nicotinic receptors, the alpha 7 nicotinic receptor, may function in an inhibitory neuronal pathway involved in this ...
Catherine E. Adams +14 more
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Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
Simultaneous Comparison of Nicotinic Receptor Antagonists on Three Nicotinic Acetylcholine Receptors
Journal of Pharmacy and Pharmacology, 1995 Abstract The relative potencies of several nicotinic cholinoceptor antagonists in producing tetanic fade and reduction of striated muscle contraction were investigated in the isolated guinea-pig oesophagus as well as the guinea-pig and rat phrenic nerve-diaphragm preparations.
Karen P Kerr +2 more
openaire +3 more sources
An Update: Enzymatic Synthesis for Industrial Applications
Angewandte Chemie International Edition, Accepted Article.Supported by rapid technological advancements, biocatalytic applications have matured into a sustainable, scalable, and cost‐competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme‐based solutions for the manufacturing of molecules with extended carbon‐carbon frameworks and multiple ...
Thomas Bayer +4 more
wiley +1 more source