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This chapter focuses on the Nidovirales order whose member families include Arteriviridae, Coronaviridae, and Roniviridae. The nidoviruses genome is an infectious, linear, positive sense RNA molecule, which is capped and polyadenylated. Based on the genome size, they are divided into two groups large and small nidoviruses.
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The genus Torovirus (order Nidovirales) includes a number of species that infect livestock. These viruses have a linear positive-sense ssRNA genome of ~25-30 kb, encoding a large polyprotein that is expressed from the genomic RNA, and several additional ...
Atkins John F, Firth Andrew E
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ABSTRACT Background and Aims Following the end of the COVID‐19 global emergency, concern has shifted to “Disease X,” a hypothetical, highly transmissible, and deadly pathogen, and Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) is a prime candidate for this. This review explores its epidemiology, mutations, transmission, and potential to become
Zubaier Ahmed +14 more
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Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor
Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang +9 more
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Ball Python Nidovirus: a Candidate Etiologic Agent for Severe Respiratory Disease in
A severe, sometimes fatal respiratory disease has been observed in captive ball pythons (Python regius) since the late 1990s. In order to better understand this disease and its etiology, we collected case and control samples and performed pathological ...
Mark D. Stenglein +11 more
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The Mesoniviridae are a newly assigned family of viruses in the order Nidovirales. Unlike other nidoviruses, which include the Coronaviridae, mesoniviruses are restricted to mosquito hosts and do not infect vertebrate cells.
Natalee D. Newton +20 more
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Transcription Kinetics in the Coronavirus Life Cycle
The steps involved in a Coronavirus infection are interconnected and exhibit complex kinetics, with some processes depending on each other, while others occur independently. Understanding the basic kinetics of major processes like translation, transcription, and virion assembly in the Coronavirus life cycle adds temporal resolution to the classical ...
Katarzyna Grelewska‐Nowotko +2 more
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Abstract Coronaviruses are highly pathogenic and therefore important human and veterinary pathogens viruses worldwide. This study is the first that produced phylogenies based on all 39 species of Coronaviridae recognized by the Coronaviridae Study Group and International Committee on Taxonomy of Viruses and has, uniquely, used several methods ...
Evgeny Mavrodiev +5 more
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Differential Susceptibility to Porcine Deltacoronavirus: Ducks Show Greater Vulnerability Than Geese
Porcine deltacoronavirus (PDCoV), an enteropathogenic coronavirus belonging to the Deltacoronavirus genus, is globally distributed and represents a significant viral enteric disease in pigs. It primarily causes severe diarrhea in pigs, especially in newborn piglets, with high fatality rates, resulting in substantial losses to the pig farming industry ...
Renqiang Liu +12 more
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The Role of the Dental Surgeon in Controlling the Dissemination of COVID-19: A Literature Review
As early as December 2019 in the province of Hubei, China, contamination of patients with pneumonia of an unknown etiology occurred. These patients presented with symptoms such as coughing, sore throat, malaise, diarrhea, high fever, and dyspnea.
Régida C. S. Batista +6 more
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