Results 51 to 60 of about 7,107 (122)

Advances in research on potential therapeutic approaches for Niemann-Pick C1 disease

Frontiers in Pharmacology
Niemann-Pick disease type C1 (NP-C1) is a rare and devastating recessive inherited lysosomal lipid and cholesterol storage disorder caused by mutations in the NPC1 or NPC2 gene.
Caifeng Zhang, Keke Su, Keke Su, Xu Jiang, Xu Jiang, Yuping Tian, Yuping Tian, Ke Li, Ke Li   +8 more
doaj   +1 more source

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain

Frontiers in Neuroscience, 2018
The endocannabinoid system (ECS) is considered to be an endogenous protective system in various neurodegenerative diseases. Niemann-Pick type C (NPC) is a neurodegenerative disease in which the role of the ECS has not been studied yet.
Eva J. van Rooden, Annelot C. M. van Esbroeck, Marc P. Baggelaar, Hui Deng, Bogdan I. Florea, André R. A. Marques, Roelof Ottenhoff, Rolf G. Boot, Herman S. Overkleeft, Johannes M. F. G. Aerts, Mario van der Stelt   +10 more
doaj   +1 more source

Effect of Arabica Coffee Husk on Plasma Lipids and Obesity on Albino Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Feeding on a high‐fat diet supplemented with Arabica coffee husks (CH) for 8 weeks led to an improvement in plasma lipids and adipose tissues in rats compared to the high‐fat diet. ABSTRACT Hyperlipidemia is a major risk factor for the development of cardiovascular diseases.
Shaheed Mohammed Alshaikhsaleh
wiley   +1 more source

Development of a neutralization assay and bioluminescent imaging mouse model for Dehong virus (DEHV) using a pseudovirus system

Microbiology Spectrum
Dehong virus (DEHV) is an emerging filamentous virus of considerable interest. However, research involving DEHV remains limited, and no suitable models exist to investigate its pathogenicity or transmission.
Xuelian Wu, Fan Liu, Tao Li, Danfeng Li, Yanru Shen, Xiaoai Zhang, Shuo Liu, Qi Jiang, Chenyan Zhao, Jianhui Nie, Youchun Wang, Baomin Feng, Wei Liu, Weijin Huang   +13 more
doaj   +1 more source

Uncovering the Causal Link Between Obesity‐Associated Genes and Multiple Sclerosis: A Systematic Literature Review

Brain and Behavior
Background: Multiple sclerosis (MS) is a multifaceted neurodegenerative disorder influenced by genetics and lifestyle. This systematic literature review investigates the role of six obesity‐associated genes, including fat mass and obesity‐associated (FTO)
Ali Jafari, Sara Khoshdooz, Melika Arab Bafrani, Farnush Bakhshimoghaddam, Hamid Abbasi, Saeid Doaei   +5 more
doaj   +1 more source

Quantitative magnetic resonance imaging of brain atrophy in a mouse model of Niemann-Pick type C disease.

PLoS ONE, 2017
In vivo magnetic resonance imaging (MRI) was used to investigate regional and global brain atrophy in the neurodegenerative Niemann Pick Type C1 (NPC1) disease mouse model.
John W Totenhagen, Adam Bernstein, Eriko S Yoshimaru, Robert P Erickson, Theodore P Trouard   +4 more
doaj   +1 more source

Identification of serum protein biomarkers in individuals with Niemann-Pick disease, type C1

Biomarker Research
Background Niemann-Pick disease, type C1 (NPC1), is a rare, fatal, neurodegenerative lysosomal disorder caused by pathological variants in NPC1. Defects in lysosomal cholesterol transport result in the accumulation of unesterified cholesterol within the ...
Khushboo Singhal, Matthew T. Menold, Niamh X. Cawley, Kiersten Campbell, Nicole Y. Farhat, Derek Alexander, Ryan K. Dale, Forbes D. Porter   +7 more
doaj   +1 more source

Role of Diffusion Tensor Imaging in Prognostication and Treatment Monitoring in Niemann-Pick Disease Type C1

Diseases, 2016
Niemann-Pick Disease, type C1 (NPC1) is a rapidly progressive neurodegenerative disorder characterized by cholesterol sequestration within late endosomes and lysosomes, for which no reliable imaging marker exists for prognostication and management ...
Meghann W. Lau, Ryan W. Lee, Robin Miyamoto, Eun Sol Jung, Nicole Yanjanin Farhat, Shoko Yoshida, Susumu Mori, Andrea Gropman, Eva H. Baker, Forbes D. Porter   +9 more
doaj   +1 more source

INNOVATIVE SPLICE SWITCHING OLIGONUCLEOTIDE THERAPY FOR NIEMANN-PICK TYPE C1 DISEASE

IBRO Neuroscience Reports, 2023
Maria Martinez De Lagran, Yu-Han Huang, Ondrej Kostov, Haiyan Zhou, Paul Gissen, Marvin Caruthers, Timothy Yu, Daniel Ginberg, Mara Dierssen   +8 more
doaj   +1 more source

The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes

Journal of Lipid Research, 2010
Niemann-Pick type C1 disease (NPC1) is an autosomal recessive lysosomal storage disorder characterized by neonatal jaundice, hepatosplenomegaly, and progressive neurodegeneration.
William S. Garver, David Jelinek, F. John Meaney, James Flynn, Kathleen M. Pettit, Glen Shepherd, Randall A. Heidenreich, Cate M. Walsh Vockley, Graciela Castro, Gordon A. Francis   +9 more
doaj   +1 more source