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Nifedipine in bronchial asthma [PDF]
In 11 patients with bronchial asthma and regular overnight falls in PEFR of greater than 15%, we demonstrated significant bronchodilation restricted only to large airways after the administration of a single dose of 10 mg of nifedipine. A statistically significant increase in PEFR, SGaw, and FEV1 was noticed at 1 and especially 2 hr after nifedipine ...
E. Vlachoianni+4 more
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Electroreduction of Nifedipine
Journal of Pharmaceutical Sciences, 1992At pH greater than 6, the nitro group of nifedipine is reduced in a four-electron step to a hydroxylamino group. At pH less than 6, the hydroxylamino derivative undergoes an acid-catalyzed dehydration, and the rate of this reaction governs the limiting current.
P. Zuman, M.M. Ellaithy
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Australian and New Zealand Journal of Medicine, 1987
Abstract An 80‐year‐old woman developed acute hepatitis following her first exposure to nifedipine. This adverse effect was characterised by fever, chills, anorexia, nausea, liver tenderness, hepatitic liver function tests and peripheral blood eosinophilia.
D R, Shaw, G M, Misan, R D, Johnson
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Abstract An 80‐year‐old woman developed acute hepatitis following her first exposure to nifedipine. This adverse effect was characterised by fever, chills, anorexia, nausea, liver tenderness, hepatitic liver function tests and peripheral blood eosinophilia.
D R, Shaw, G M, Misan, R D, Johnson
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Nifedipine-Aminophylline Interaction
Survey of Anesthesiology, 1988Two patients suffered serious nifedipine side effects that were reversed by intravenous ...
L. Kalra, S. J. P. Ariaraj, M. F. Bone
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The American Journal of Medicine, 1986
A 59-year-old man ingested 900 mg of nifedipine. Profound hypotension, sinus and atrioventricular node dysfunction, and hyperglycemia resulted. The patient's condition responded favorably to aggressive treatment with intravenous fluids, calcium, and dopamine.
D M, Herrington+2 more
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A 59-year-old man ingested 900 mg of nifedipine. Profound hypotension, sinus and atrioventricular node dysfunction, and hyperglycemia resulted. The patient's condition responded favorably to aggressive treatment with intravenous fluids, calcium, and dopamine.
D M, Herrington+2 more
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The American Journal of Cardiology, 1985
Many investigators have studied the potential interactions between calcium-channel antagonists and digoxin. Digoxin is usually well absorbed, and its excretion is dependent on renal mechanisms, primarily glomerular filtration. Several studies have reported a decrease in digoxin clearance and an increase of approximately 50% in digoxin levels when ...
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Many investigators have studied the potential interactions between calcium-channel antagonists and digoxin. Digoxin is usually well absorbed, and its excretion is dependent on renal mechanisms, primarily glomerular filtration. Several studies have reported a decrease in digoxin clearance and an increase of approximately 50% in digoxin levels when ...
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Gingival sequestration of nifedipine in nifedipine-induced gingival overgrowth
The Lancet, 1992The mechanism of gingival overgrowth associated with long-term use of nifedipine and of other drugs that affect calcium homoeostasis, such as cyclosporin and phenytoin, is unknown. With an ultrasensitive assay, we measured the pharmacokinetics of nifedipine in plasma and gingival crevicular fluid (GCF) of nine patients receiving this drug for angina ...
Janice S. Ellis+3 more
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Chitosan microspheres of nifedipine and nifedipine-cyclodextrin inclusion complexes
International Journal of Pharmaceutics, 1996Chitosan microspheres of nifedipine and nifedipine cyclodextrin complexes were prepared by the glutaraldehyde cross-linking of chitosan. Microspheres having different degrees of swelling were made by varying the cross-linking density. Drug incorporation efficiencies exceeding 70 % could be achieved for this drug.
Ivan Jalšenjak+3 more
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