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Electroreduction of Nifedipine

Journal of Pharmaceutical Sciences, 1992
At pH greater than 6, the nitro group of nifedipine is reduced in a four-electron step to a hydroxylamino group. At pH less than 6, the hydroxylamino derivative undergoes an acid-catalyzed dehydration, and the rate of this reaction governs the limiting current.
P. Zuman, M.M. Ellaithy
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Nifedipine in bronchial asthma [PDF]

open access: possibleJournal of Allergy and Clinical Immunology, 1983
In 11 patients with bronchial asthma and regular overnight falls in PEFR of greater than 15%, we demonstrated significant bronchodilation restricted only to large airways after the administration of a single dose of 10 mg of nifedipine. A statistically significant increase in PEFR, SGaw, and FEV1 was noticed at 1 and especially 2 hr after nifedipine ...
E. Vlachoianni   +4 more
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NIFEDIPINE HEPATITIS

Australian and New Zealand Journal of Medicine, 1987
Abstract An 80‐year‐old woman developed acute hepatitis following her first exposure to nifedipine. This adverse effect was characterised by fever, chills, anorexia, nausea, liver tenderness, hepatitic liver function tests and peripheral blood eosinophilia.
D R, Shaw, G M, Misan, R D, Johnson
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Nifedipine overdose

The American Journal of Medicine, 1986
A 59-year-old man ingested 900 mg of nifedipine. Profound hypotension, sinus and atrioventricular node dysfunction, and hyperglycemia resulted. The patient's condition responded favorably to aggressive treatment with intravenous fluids, calcium, and dopamine.
D M, Herrington   +2 more
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Nifedipine-Aminophylline Interaction

Survey of Anesthesiology, 1988
Two patients suffered serious nifedipine side effects that were reversed by intravenous ...
L. Kalra, S. J. P. Ariaraj, M. F. Bone
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Nifedipine and Erythromelalgia

Annals of Internal Medicine, 1983
Excerpt To the editor: Erythromelalgia, a skin eruption with intense red discoloration, elevated skin temperature, and burning pain, usually involves the hands, feet, or lower legs.
Marvin B. Padnick   +2 more
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Digoxin and nifedipine

The American Journal of Cardiology, 1985
Many investigators have studied the potential interactions between calcium-channel antagonists and digoxin. Digoxin is usually well absorbed, and its excretion is dependent on renal mechanisms, primarily glomerular filtration. Several studies have reported a decrease in digoxin clearance and an increase of approximately 50% in digoxin levels when ...
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