Results 91 to 100 of about 7,782 (210)

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
core   +1 more source

Medicinal Plants of Chile: Evaluation of their Anti-Trypanosoma cruzi Activity [PDF]

, 2013
San Martin, J (San Martin, Jose). Univ Talca, Inst Biol Vegetal & Biotecnol, Talca, ChileThe extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity.
Christen, P., Ferreira, J., Kemmerling, U., Lopez-Munoz, R., Maya, J.D., Morello, A., Munoz, O.M., San Martin, J.   +7 more
core   +2 more sources

The pharmacokinetics of nifurtimox in chronic renal failure

European Journal of Clinical Pharmacology, 1992
The pharmacokinetics of nifurtimox, a drug used in the treatment of Trypanosoma cruzi infections, has been studied in seven patients with chronic renal failure undergoing haemodialysis, and in seven healthy subjects. Each subject took nifurtimox 15 mg.kg-1 orally and blood samples were obtained for 10 h after administration.
González-Martin, G., Thambo, S., Paulos, C., Vásquez, I., Paredes, J.   +4 more
openaire   +3 more sources

Chagas Disease: “The Kiss of Death” [PDF]

, 2015
Chagas disease is a vector transmitted disease also known as American trypanosomiasis. Chagas disease is classified as a protist or protozoa, which is a simplified version of ‘animal-like single celled organism that is like a multicellular organism ...
Castro, Stacy, Rogers, Jessica
core   +1 more source

Drug Resistance in Eukaryotic Microorganisms [PDF]

, 2016
Eukaryotic microbial pathogens are major contributors to illness and death globally. Although much of their impact can be controlled by drug therapy as with prokaryotic microorganisms, the emergence of drug resistance has threatened these treatment ...
A Abdolrasouli, A Cassone, A Chowdhary, A Ecker, A Heinberg, A Kulshrestha, A Mbengue, A Mukherjee, A Selmecki, A Selmecki, A Trochine, AC Coelho, AF Cowman, AF Cowman, AH Fairlamb, AH Fairlamb, AJ Kazibwe, AM Abd-Alla, AM Dondorp, AM Mejia, AY Sokolova, B Chawla, B Gourbal, B Zingales, BD Alexander, BJ Kullberg, BK Kubata, BM Mony, BS Hall, BS Hall, BS McGwire, C Amaratunga, C Amaratunga, C Brochu, C Costa, C Mathieu, C Sisowath, C Wongsrichanalai, CA Morillo, CD Goodman, CF Oliva, CP Sanchez, CP Sanchez, D Begolo, D Rojo, DA Fidock, DS Guttery, DS Perlin, DW Denning, E Castanys-Munoz, E Chatelain, E Kussell, E Matovu, E Shor, E Snelders, E Snelders, E Vermeulen, E Wang, F Ariey, F Nosten, FC Odds, FE Graf, FE Graf, FJ Perez-Victoria, FJ Perez-Victoria, FJ Perez-Victoria, FM Fernandez, G Awasthi, G Blum, G Priotto, GA Canuto, GA Pankey, GM Nayyar, GW Rose, H Noedl, HL Callahan, HM Andrade, HY Sun, I Keren, I Molina, IH Cheeseman, IM Vincent, IM Vincent, IM Vincent, J Hemingway, J Robays, J Song, J Straimer, J Yuan, JA Urbina, JA Urbina, JC Dias, JC Dias, JC Munday, JC Wootton, JI Manzano, JL Nishikawa, JM Perez-Victoria, JR Franco, JW van der Linden, K El Fadili, K Lewis, K Seifert, KC Gray, KJ Kwon-Chung, KW Dantzler, L Denoeud-Ndam, L Glover, LE Cowen, LE Cowen, M Berg, M Ghorbal, M Maharjan, M Manske, M Plourde, M Rakotomanga, M Rakotomanga, M Venkatesan, M Woolhouse, M Woolhouse, MA Pfaller, MB Rogers, MC Brotherton, MD LaFleur, MD LaFleur, MK Kinga, MK Laufer, MR Perry, MR Perry, MR Perry, MT Duraisingh, MT Ferdig, N Baker, N Biyani, N Marquis, N Regev-Rudzki, N Rovira-Graells, NJ White, NR Cohen, NS Carter, O Epaulard, O Miotto, P Baiocco, P Maser, P Shaked-Mishan, P Vandeputte, P Wang, PE Verweij, PJ Hotez, PK Fyfe, PL Olliaro, PP Pyana, PY Mantel, R Kumar, R Mukhopadhyay, R Prasad, RD Cannon, S Alsford, S Decuypere, S Decuypere, S Dey, S Dey, S Imhof, S Kucharikova, S Leroux, S Mandal, S Mok, S Patterson, S Pelleau, S Pulcini, S Rijal, S Sundar, S Sundar, S Takala-Harrison, S Wyllie, S Wyllie, S Wyllie, S Wyllie, SA Flowers, SC Welburn, SD Singh, SE Kidd, SG Valderramos, SK Katiyar, SMF Murta, SR Meshnick, SR Wilkinson, TE Wellems, TE Wellems, TPC Dorlo, V Lutje, W Peters, Y Sterkers, Y Zhou   +193 more
core   +4 more sources

Effect of drugs on Trypanosoma cruzi and on its interaction with heart muscle cell in vitro Efeito de drogas sobre o Trypanosoma cruzi e sua interação com células musculares cardíacas in vitro

Memorias do Instituto Oswaldo Cruz, 1987
Megazol, nifurtimox, benznidazol and allopurinol were investigated, by light and electron µscopy, for their action on T. cruzi. Both the direct effect upon amastigote and trypomastigote forms and the effect upon the interaction of heart muscle cells (HMC)
Solange L. de Castro, Maria de Nazareth L. de Meirelles   +1 more
doaj   +1 more source

Chagas disease: Present status of pathogenic mechanisms and chemotherapy

Biological Research, 2010
There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma cruzi. It is a chronic disease,
Juan Diego Maya, Myriam Orellana, Jorge Ferreira, Ulrike Kemmerling, Rodrigo López-Muñoz, Antonio Morello   +5 more
doaj  

Padrão isoenzimático da cepa Y do Trypanosoma cruzi após quimioterapia específica Isoenzymatic pattern of Trypanosoma cruzi Y strain following specific chemoterapy

Memorias do Instituto Oswaldo Cruz, 1989
Foi estudado o perfil isoenzimático da cepa Y do Trypanosoma cruzi isolada de camundongos tratados e não curados com o Nufurtimox (Bay 2502) ou com o Benzonidazol (Ro 7.1051), submetida à passagens em camundongos recém-nascidos e a seguir inoculada nos ...
Rosângela Castro Silva, Christiane M. G. Santiago, Albélia Lima Pontes, Sonia G. Andrade   +3 more
doaj   +1 more source

Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.

Biological Research, 2004
Proteins rich in sulfhydryl groups, such as metallothionein, are present in several strains of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease.
JUAN DIEGO MAYA, ANDRÉS RODRÍGUEZ, LAURA PINO, ADRIANA PABÓN, JORGE FERREIRA, MARIO PAVANI, YOLANDA REPETTO, ANTONIO MORELLO   +7 more
doaj  

Serological and parasitological response in chronic Chagas patients 3 years after nifurtimox treatment

BMC Infectious Diseases, 2013
Background With declining vectorial transmission, Chagas disease predominantly affects adults nowadays. The efficacy of nifurtimox in the chronic phase in adult patients is poorly known, particularly in regions where there is no risk of reinfection ...
Jackson Yves, Chatelain Eric, Mauris Anne, Holst Marylise, Miao Qianqian, Chappuis Francois, Ndao Momar   +6 more
doaj   +1 more source