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BackgroundChagas disease is an anthropozoonosis caused by Trypanosoma cruzi. Two drugs are currently used for the etiological treatment of the disease: Nifurtimox (Lampit) and Benznidazole.
Fiorella Bianchi +11 more
doaj +1 more source
Nifurtimox-Eflornithine Combination Therapy for Second-Stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières Experience in the Democratic Republic of the Congo [PDF]
Since 2009, nifurtimox-eflornithine combination therapy (NECT) has raised great hopes for the treatment of second-stage human African trypanosomiasis.
Alirol, Emilie +6 more
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Pacientes na fase crônica da doença de Chagas foram tratados com corticóide em virtude de afecções associadas e, a fim de tentar coibir reativação da infecção pelo Trypanosoma cruzi, houve uso concomitante do nifurtimox.
Anis Rassi +3 more
doaj
Human African trypanosomiasis in endemic populations and travellers [PDF]
Human African trypanosomiasis (HAT) or sleeping sickness is caused by the protozoan parasites Trypanosoma brucei (T.b.) gambiense (West African form) and T.b.
Blum, J., Hatz, C., Neumayr, A.
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Tratamento da fase crônica da doença de Chagas com nifurtimox associado a corticóide
Dez pacientes com doença de Chagas em fase crônica foram tratados durante 60 dias, com uma única exceção, por meio de nifurtimox (8 a 9mg/kg/dia) conjuntamente com betametasona (doses progressivamente decrescentes a partir de 9mg/dia).
Anis Rassi +6 more
doaj
Melarsoprol-Free Drug Combinations for Second-Stage Gambian Sleeping Sickness: The Way to Go. [PDF]
Balasegaram +6 more
core +2 more sources
A Expressão Global da Doença de Chagas – Oportunidades Emergentes e Impacto em Portugal [PDF]
Chagas disease, caused by the protozoan Trypanosoma cruzi is endemic in the countries of Central and South America. Despite vector control programs and other measures taken in the blood banks and maternity hospitals, it is estimated that there are about ...
Cortez, J +4 more
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Genotoxicity testing of antiparasitic nitrofurans in the Drosophila wing somatic mutation and recombination test [PDF]
Nifurtimox and eight structurally related 5-nitrofuran compounds active against Trypanosoma cruzi were tested for genotoxicity in the wing somatic mutation and recombination test in Drosophila melanogaster.
Graf, Ulrich, Moraga, Angeles Alonso
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