Results 151 to 160 of about 7,787 (204)

In Silico Studies and Biological Evaluation of Thiosemicarbazones as Cruzain-Targeting Trypanocidal Agents for Chagas Disease. [PDF]

Pharmaceutics
Meier L, de Melo MFCV, Abreu HR, Oliveira IME, Sens L, Doring TH, Krogh R, Beatriz A, Andricopulo AD, Saba S, de Oliveira AS, Rafique J.   +11 more
europepmc   +1 more source

TropMol-Caipora: A Cloud-Based Web Tool to Predict Cruzain Inhibitors by Machine Learning. [PDF]

ACS Omega
Doring TH.
europepmc   +1 more source

Trypanocidal Activity of Dual Redox-Active Quinones: Trypanosoma cruzi Mitochondrion as a Target Organelle In Vitro and Anti-Inflammatory Properties In Vivo. [PDF]

Pathogens
Duarte RB, Ramos VFS, Barbosa JMC, Oliveira GM, Diogo EBT, Almeida RG, Lennox AJJ, da Silva Júnior EN, Pedra-Rezende Y, Menna-Barreto RFS.   +9 more
europepmc   +1 more source

New regimens of benznidazole for the treatment of chronic Chagas disease in adult participants in indeterminate form or with mild cardiac progression (NuestroBen study): protocol for a phase III randomised, multicentre non-inferiority clinical trial. [PDF]

BMJ Open
Marques T, Forsyth C, Barreira F, Lombas C, Blum de Oliveira B, Laserna M, Molina I, Bangher MDC, Javier Fernández R, Lloveras S, Fernández ML, Scapellato P, Patterson P, Garcia W, Ortiz L, Schijman A, Moreira OC, García L, Viele K, Longhi S, Vaillant M, Tipple C, Fraisse L, Silvestre-Sousa A, Sosa-Estani S, Pinazo MJ.   +25 more
europepmc   +1 more source

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Polarographic Study of Nifurtimox

Journal of Pharmaceutical Sciences, 1990
Nifurtimox is polarographically reducible over the whole pH range, the nitro group being reduced to the hydroxylamine group in a 4e process and subsequently the amine being formed in a 2e process at a pH value below 4. The C = N-N linkage is reduced by a mechanism involving reductive fission of the N-N bond.
Squella Serrano, Juan, Muñoz, W., Núñez Vergara, Luis, Paulos, Claudio   +3 more
openaire   +2 more sources

Update on nifurtimox for treatment of Chagas disease

Drugs of Today, 2021
Chagas disease is a vector-borne neglected tropical disease caused by Trypanosoma cruzi. It is a systemic and chronic parasitic infection which is endemic in 21 countries with 10 million cases worldwide and 12,000 annual deaths. Around 70 million people in the Americas are at risk of contracting this disease, and less than 1% of infected people are ...
R, Thakare, A, Dasgupta, S, Chopra
openaire   +2 more sources

A New Analogue of Nifurtimox

Acta Crystallographica Section C Crystal Structure Communications, 1996
1-¿[(5-Nitro-2-furyl)methylene]amino¿-1,2,4-triazole, C7H5N5O3, is a new analogue of nifurtimox with activity against Tripanosoma cruzi. In the crystal structure, the molecule lies on a mirror plane and has an E-sZ conformation along the N = C-C moiety. The molecules are linked through C-H...O and C-H...N interactions.
I, Caracelli, F M, Stamato, B, Mester, M, Paulino, H, Cerecetto   +4 more
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Trypanosoma cruzi: Nifurtimox's effect on infectivity

Experimental Parasitology, 1977
Abstract Mice were protected from infection with Trypanosoma cruzi , Tulahuen strain, by Nifurtimox [3-methyl-4-(5′-nitrofurfurylidene-amino)tetrahydro-4 H -1, 4-thiazine-1,1-dioxide] treatment with doses currently used for human therapy (10 mg/kg/day).
R L, Cardoni, M T, Rimoldi, M M, de Bracco   +2 more
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Mutagenicity of nifurtimox in Escherichia coli

Mutation Research/Genetic Toxicology, 1980
The effects of nifurtimox, a nitrofuran derivative, on killing and mutation induction in 3 Escherichia coli strains having different DNA-repair systems for UV lesion were studied and compared with the effects of furylfuramide. Nifurtimox induces mutations at a high frequency in both Hs3OR (uvrA-) and H/r30R (radiation-resistant), although no ...
T, Ohnishi, Y, Ohashi, K, Nozu, S, Inoki
openaire   +2 more sources