Results 161 to 170 of about 7,782 (210)
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Acta Crystallographica Section C Crystal Structure Communications, 1996
1-¿[(5-Nitro-2-furyl)methylene]amino¿-1,2,4-triazole, C7H5N5O3, is a new analogue of nifurtimox with activity against Tripanosoma cruzi. In the crystal structure, the molecule lies on a mirror plane and has an E-sZ conformation along the N = C-C moiety. The molecules are linked through C-H...O and C-H...N interactions.
I, Caracelli +4 more
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1-¿[(5-Nitro-2-furyl)methylene]amino¿-1,2,4-triazole, C7H5N5O3, is a new analogue of nifurtimox with activity against Tripanosoma cruzi. In the crystal structure, the molecule lies on a mirror plane and has an E-sZ conformation along the N = C-C moiety. The molecules are linked through C-H...O and C-H...N interactions.
I, Caracelli +4 more
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Trypanosoma cruzi: Nifurtimox's effect on infectivity
Experimental Parasitology, 1977Abstract Mice were protected from infection with Trypanosoma cruzi , Tulahuen strain, by Nifurtimox [3-methyl-4-(5′-nitrofurfurylidene-amino)tetrahydro-4 H -1, 4-thiazine-1,1-dioxide] treatment with doses currently used for human therapy (10 mg/kg/day).
R L, Cardoni +2 more
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Mutagenicity of nifurtimox in Escherichia coli
Mutation Research/Genetic Toxicology, 1980The effects of nifurtimox, a nitrofuran derivative, on killing and mutation induction in 3 Escherichia coli strains having different DNA-repair systems for UV lesion were studied and compared with the effects of furylfuramide. Nifurtimox induces mutations at a high frequency in both Hs3OR (uvrA-) and H/r30R (radiation-resistant), although no ...
T, Ohnishi, Y, Ohashi, K, Nozu, S, Inoki
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Further trials of nifurtimox in mucocutaneous leishmaniasis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1981At a dosage level of 8 to 10 mg/kg body-weight daily for 120 days nifurtimox was associated with clinical healing of cutaneous leishmaniasis in five of eight patients. At a dosage level of 20 mg/kg body-weight daily for 10 days in six of 10 patients the skin ulcer healed. Results and the reasons why both schemes are impracticable are briefly discussed.
M F, Guerra +3 more
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Antiparasitic Prodrug Nifurtimox: Revisiting its Activation Mechanism
Future Microbiology, 2011EVALUATION OF: Hall BS, Bot C, Wilkinson SR. Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites. J. Biol. Chem. 286, 13088-13095 (2011). The prodrug nifurtimox has been one of the pharmacologic alternatives to treat Chagas disease and currently forms part of a combinational therapy to treat West African
Hugo, Cerecetto, Mercedes, González
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Lipid alterations induced by Nifurtimox in Trypanosoma cruzi
Molecular and Biochemical Parasitology, 1986The influence of growth in the presence of nifurtimox on total lipids of Trypanosoma cruzi epimastigotes was determined. Nifurtimox-treated organisms showed greater amounts of unsaturated fatty acids as compared with control cells. 18:2 was the major component in the total esterified lipid fraction.
E, Barreto-Bergter +2 more
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Nifurtimox in the treatment of South American leishmaniasis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1979A trial of Nifurtimox (Lampit) in 26 patients with mucocutaneous leishmaniasis is reported. 13 patients with cutaneous lesions and 13 patients with mucosal disease were treated with a daily oral divided dose of 10 mg/kg body-weight for 30 days. 46% of the cutaneous cases and only 15% of the mucosal cases apparently responded to this regimen during at ...
P D, Marsden +4 more
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Nifurtimox Plus Pyrimethamine for Treatment of Murine Toxoplasmosis
The Journal of Parasitology, 1998In the search for novel antitoxoplasmic agents, we evaluated the efficacy of nifurtimox (3-methyl-4[5'-nitrofurfurylidene-amino]-tetrahydroe-4H-1,4- thiazine-1,1-dioxide), an antiprotozoal drug effective against trypanosomiasis, in an experimental model of acute toxoplasmosis in mice.
L, Aguirre-Cruz, O, Velasco, J, Sotelo
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