Results 41 to 50 of about 7,787 (204)

Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
In vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Nicoli Dias Oliveira, Mariana Cintra Pagotti, Lucas Antonio de Lima Paula, Mariana Zaramello Paixão, Daiane Albino dos Santos, Renata Faleiros de Freitas, Sérgio Ricardo Ambrósio, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Lizandra Guidi Magalhães   +9 more
wiley   +1 more source

Evaluating 5-nitrofurans as trypanocidal agents [PDF]

, 2013
The nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targeting Trypanosoma brucei, the causative agent of human African trypanosomiasis.
Alvarez, G, Bot, C, Cerecetto, H, Di Maio, D, Gonzalez, M, Hall, BS, WILKINSON, SR   +6 more
core   +1 more source

Chemical Constituents and Biological Activities of Oxandra (Annonaceae): A Review

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Oxandra (Annonaceae) comprises 29 species distributed across South and Central America. Despite this diversity, the genus remains under‐investigated. This study presents the first comprehensive review of the chemical composition and biological activities of Oxandra species, utilizing databases such as SciFinder, ScienceDirect, PubMed, and ...
Rayssa Cota Lopes, Francisco Paiva Machado, Mateus de Freitas Brito, Thalisson Amorim de Souza, Lucas Silva Abreu   +4 more
wiley   +1 more source

Antiparasitic Effect of Stilbene and Terphenyl Compounds against Trypanosoma cruzi Parasites

Pharmaceuticals, 2021
Background: Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi. No progress in the treatment of this pathology has been made since Nifurtimox was introduced
Federica Bruno, Germano Castelli, Fabrizio Vitale, Simone Catanzaro, Valeria Vitale Badaco, Marinella Roberti, Claudia Colomba, Antonio Cascio, Manlio Tolomeo   +8 more
doaj   +1 more source

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi

ChemMedChem, Volume 21, Issue 1, January 2026.
Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco, Jodieh Oliveira Santana Varejão, Isabela Penna Ceravolo, Victória Miranda Machado, Antoniana Ursine Krettli, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Felipe Terra Martins, Eduardo Jorge Pilau, Vinícius Ribeiro Montes, Markus Kohlhoff, Eduardo V. V. Varejão   +11 more
wiley   +1 more source

First report of an acute case of Chagas disease in the municipality of Miraflores, Guaviare, Colombia

Revista Peruana de Medicina Experimental y Salud Pública
We present a case of acute phase Chagas disease in a 40-year-old male patient from Vereda Buenos Aires, Municipality of Miraflores, Department of Guaviare. The patient attended the emergency department with fever, headache, asthenia, adynamia and dysuria.
José Ziadé Benítez, Diana Cedeño Díaz, Luz Alba Colorado, Laureano Mosquera Murillo, María Trinidad Orozco, Sandra Vallecilla, Julio Cesar Padilla, Mario J. Olivera   +7 more
doaj   +1 more source

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes [PDF]

Journal of Antimicrobial Chemotherapy, 2015
In response to reports of Trypanosoma brucei resistance to the nitroaromatic drug nifurtimox, we evaluated the potential of antituberculosis nitrofuran isoxazolines as inhibitors of trypanosome growth.The susceptibility of T. brucei brucei was assessed in vitro.
Bruhn, David F., Wyllie, Susan, Rodríguez-Cortés, Adaris, Carrillo, Angela K., Rakesh, Guy, R. Kiplin, Fairlamb, Alan H., Lee, Richard E.   +7 more
openaire   +3 more sources

Current and future chemotherapy for Chagas disease [PDF]

, 2015
Luís Gaspar is thankful to FCT for funding (scholarship reference: SFRH/BD/81604/2011). The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreement No.602773 (Project KINDRED)
Cordeiro-da-Silva, Anabela, Coron, Ross P, Costantino, Luca, Costi, Maria Paola, Ferrari, Stefania, Freitas-Junior, Lucio H, Gaspar, Luís, McKerrow, James H, Moraes, Carolina B, Siqueira-Neto, Jair L, Smith, Terence Kenneth   +10 more
core   +1 more source

Enantiocomplementary Bioreduction of Flexible Ring N‐(3‐Oxobutyl)Heterocycles Providing Enantiopure Chiral Fragments for Drug Discovery

ChemBioChem, Volume 26, Issue 19, October 3, 2025.
Bioreduction of flexible ring N‐(3‐oxobutyl)‐heterocycles mediated by enantiocomplementary recombinant alcohol dehydrogenases [an (S)‐selective one from Rhodococcus aetherivorans (RaADH), and an (R)‐selective one from Lactobacillus kefir (LkADH)], as whole‐cell biocatalysts results in enantiopure (S)‐ and (R)‐alcohols (ee > 99%), which are promising ...
Máté Gergő Honvári, Levente András Mócza, Bence Attila Kucsinka, Pál Csuka, Viktória Bódai, Diana Maria Scrob, László Poppe, Gábor Hornyánszky   +7 more
wiley   +1 more source

Dipyridamole potentiated the trypanocidal effect of nifurtimox and improved the cardiac function in NMRI mice with acute chagasic myocarditis

Memorias do Instituto Oswaldo Cruz
BACKGROUND As chronic Chagas disease does not have a definitive treatment, the development of alternative therapeutic protocols is a priority. Dipyridamole (DPY) is an alternative to counteract the pathophysiological phenomena involved in Chagas ...
Sonia Santeliz, Peter Caicedo, Elidiosmar Giraldo, Carmen Alvarez, María-Daniela Yustiz, Claudina Rodríguez-Bonfante, Romina Bonfante-Rodríguez, Rafael Bonfante-Cabarcas   +7 more
doaj   +1 more source