Results 51 to 60 of about 7,787 (204)
Memorias do Instituto Oswaldo Cruz, 2008 Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas disease. As recent studies have de-monstrated cardiotoxic effects of Nfx, we attempted to determine whether Bz behaves similarly.
María Montalto de Mecca +3 more
doaj +1 more source
Review of Chagas Disease and Treatment Obstacles to Eradication [PDF]
, 2019 The World Health Organization and the Center for Disease Control reports Chagas disease, or American trypanosomiasis, as a major neglected tropical disease prevalent in 21 endemic Latin American countries.
Sherman, Emily
core +1 more source
African Trypanosomes undermine humoral responses and vaccine development : link with inflammatory responses? [PDF]
, 2017 African trypanosomosis is a debilitating disease of great medical and socioeconomical importance. It is caused by strictly extracellular protozoan parasites capable of infecting all vertebrate classes including human, livestock, and game animals.
Achcar +160 more
core +1 more source
Natural Products from Mexican Medicinal Plants as Promising Trypanocidal Drugs
ChemistrySelect, Volume 10, Issue 37, October 6, 2025.Chagas disease (American Trypanosomiasis) is caused by the protozoan Trypanosoma cruzi. Worldwide it is one of the seventeen neglected tropical diseases. There is a need of new drugs. This review assesses the literature (2012‐2024) of secondary metabolites isolated from Mexican plants active against this parasite.
Karla Daniela Rodríguez‐Hernández +2 more
wiley +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2009 Introducción. Los tratamientos actuales para la enfermedad de Chagas son insatisfactorios y sólo existen dos medicamentos disponibles. La búsqueda de alternativas terapéuticas es prioritaria. La hexadecilfosfocolina (miltefosina) ha mostrado actividad in
Patricia Escobar +5 more
doaj +1 more source
Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]
, 2017 Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core +1 more source
Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs. [PDF]
, 2012 Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I nitroreductases, enzymes found ...
Alsford +68 more
core +1 more source
Pregnancy, Volume 1, Issue 4, July 2025.Abstract Introduction Over 300,000 people living in the United States are estimated to have Chagas disease, a condition for which mother to child transmission may occur and early diagnosis is essential to reduce Chagas‐related morbidity and mortality. This study evaluated positive Trypanosoma cruzi (T. cruzi) screening serology among maternal donors of
Naseem Alavian +6 more
wiley +1 more source
Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds [PDF]
, 2010 RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African ...
Alibu, Vincent P. +6 more
core +4 more sources
Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
Molecules, 2015 Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox.
Ana L. Legarda-Ceballos +9 more
doaj +1 more source