Results 61 to 70 of about 7,787 (204)

Nifurtimox Inhibits the Progression of Neuroblastoma in vivo [PDF]

Journal of Cancer, 2019
Neuroblastoma was one of the most life-threatening cancer developed in children, yet the conventional therapies currently used leave an unmet gap for clinical requirements. Temozolomide is the first line of drug in the treatment of neuroblastorma nowadays. Giving the fact that temozolomide treatment offered limited healing effect and patients responded
Kong, Eryan, Zhu, Jiangli, Wu, Wentao, Ren, Hongguang, Jiao, Xuemiao, Wang, Hui, Zhang, Zhongjian   +6 more
openaire   +2 more sources

Cytotoxicity and trypanocidal activity of nifurtimox encapsulated in ethylcyanoacrylate nanoparticles

Biological Research, 2002
The aim of the present study was to study the trypanocidal activity of nanoparticles loaded with nifurtimox in comparison with the free drug against Trypanosoma cruzi, responsible for Chagas' disease.
GITTITH SÁNCHEZ, DANIELA CUELLAR, INES ZULANTAY, MARTA GAJARDO, GUILLERMO GONZÁLEZ-MARTIN   +4 more
doaj  

Activation of bicyclic nitro-drugs by a novel nitroreductase (NTR2) in Leishmania [PDF]

, 2016
Drug discovery pipelines for the "neglected diseases" are now heavily populated with nitroheterocyclic compounds. Recently, the bicyclic nitro-compounds (R)-PA-824, DNDI-VL-2098 and delamanid have been identified as potential candidates for the treatment
Berriman, Matthew, Fairlamb, Alan H., Foth, Bernardo J., Norval, Suzanne, Patterson, Stephen, Read, Kevin D., Roberts, Adam J., Wyllie, Susan   +7 more
core   +4 more sources

Synthesis of Quinic Acid‐Derived Sialylmimetics and Their Effects on T. cruzi and Trans‐Sialidase

ChemistrySelect, Volume 10, Issue 16, April 25, 2025.
The synthesis of sialylmimetic hybrids using quinic and shikimic acids as precursors was achieved in a single synthetic route to produce two isomers (5S‐ and 5R), incorporating the 4‐(4‐nitrophenyl)‐1H‐1,2,3‐triazole units, as novel leads for Chagas disease treatment.
Dayan Setton Amancio, Guilherme Martins da Silva, Carlos Henrique Tomich de Paula da Silva, Luis Otávio Bunhotto Zamoner, Lizandra Guidi Magalhães, Guilherme Cecilio Lima, Mariana Zaramello da Paixão, Ivone Carvalho   +7 more
wiley   +1 more source

Flavin‐Dependent Nitroreductases: Privileged Enzymes for Chemical and Photochemical Synthesis

ChemCatChem, Volume 17, Issue 5, March 6, 2025.
This review summarizes the functional, structural, and mechanistic properties of flavin‐dependent nitroreductases and highlights their usefulness for the synthesis of nitrogen‐containing compounds. Recent advances in enzyme and cofactor engineering, as well as in the use of nitroreductases in photobiocatalytic approaches, are emphasized.
Sara Russo, Alejandro Prats Luján, Marco W. Fraaije, Gerrit J. Poelarends   +3 more
wiley   +1 more source

Mechanism of action of a nitroimidazole-thiadiazole derivate upon Trypanosoma cruzi tissue culture amastigotes

Memorias do Instituto Oswaldo Cruz, 1990
Megazol (CL 64,855) a very effective drug in experimental infections by Trypanosoma cruzi, and also in in vitro assays with vertebrate forms of the parasite, had its parasite, had its activity upon macromolecule biosynthesis tested using tissue culture ...
Solange L. de Castro, Maria de Nazareth L. Meirelles   +1 more
doaj   +1 more source

Phenotypic diversity and drug susceptibility of Trypanosoma cruzi TcV clinical isolates. [PDF]

PLoS ONE, 2018
Trypanosoma cruzi is a genetically heterogeneous group of organisms that cause Chagas disease. It has been long suspected that the clinical outcome of the disease and response to therapeutic agents are, at least in part, related to the genetic ...
Luz P Quebrada Palacio, Mariela N González, Yolanda Hernandez-Vasquez, Alina E Perrone, Adriana Parodi-Talice, Jacqueline Bua, Miriam Postan   +6 more
doaj   +1 more source

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

Effect of the host specific treatment in the phagocytosis of Trypanosoma cruzi blood forms by mouse peritoneal macrophages

Memorias do Instituto Oswaldo Cruz, 1990
Single doses of drugs active aginst Trypanosoma cruzi (megazol, nifurtimox and benznidazole) induce a rapid clearence of the blood parasites in experimentally infected mice.
Eliane Lages-Silva, Leny S. Filardi, Zigman Brener   +2 more
doaj   +1 more source

Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy

Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.
A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source