Results 61 to 70 of about 7,782 (210)

Chemical Constituents and Biological Activities of Oxandra (Annonaceae): A Review

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Oxandra (Annonaceae) comprises 29 species distributed across South and Central America. Despite this diversity, the genus remains under‐investigated. This study presents the first comprehensive review of the chemical composition and biological activities of Oxandra species, utilizing databases such as SciFinder, ScienceDirect, PubMed, and ...
Rayssa Cota Lopes, Francisco Paiva Machado, Mateus de Freitas Brito, Thalisson Amorim de Souza, Lucas Silva Abreu   +4 more
wiley   +1 more source

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols

Molecules, 2015
Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox.
Ana L. Legarda-Ceballos, Esther del Olmo, Julio López-Abán, Ricardo Escarcena, Luis A. Bustos, Cristina Fonseca-Berzal, Alicia Gómez-Barrio, Juan C. Dib, Arturo San Feliciano, Antonio Muro   +9 more
doaj   +1 more source

Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs. [PDF]

, 2012
Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I nitroreductases, enzymes found ...
Alsford, Alsford, Armstrong, Begleiter, Belinda S. Hall, Bern, Bienen, Bot, Brun, Bryant, Chaudhuri, Chen, Clarkson, Danson, Danson, Emma Louise Meredith, Ernster, Faeder, Fang, Fang, Fang, Fang, Garavaglia, Gascon, Goodwin, Guerra, Hall, Hall, Hall, Henderson, Hirumi, Hoet, Hu, Iyanagi, Jaiswal, Jarrom, Koder, Kubata, Müller, Nillius, Nivinskas, Nixon, O'Brien, Pal, Parkinson, Peterson, Pinto, Powis, Purkayastha, Race, Race, Ramos, Rassi, Shane R. Wilkinson, Stein, Stuart, Surve, Tatsumi, Tedeschi, Torri, Torri, Urech, Ward, Watanabe, Whiteway, Wilkinson, Yan, Zenno, Zenno   +68 more
core   +1 more source

Nifurtimox Inhibits the Progression of Neuroblastoma in vivo [PDF]

Journal of Cancer, 2019
Neuroblastoma was one of the most life-threatening cancer developed in children, yet the conventional therapies currently used leave an unmet gap for clinical requirements. Temozolomide is the first line of drug in the treatment of neuroblastorma nowadays. Giving the fact that temozolomide treatment offered limited healing effect and patients responded
Kong, Eryan, Zhu, Jiangli, Wu, Wentao, Ren, Hongguang, Jiao, Xuemiao, Wang, Hui, Zhang, Zhongjian   +6 more
openaire   +2 more sources

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi

ChemMedChem, Volume 21, Issue 1, January 2026.
Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco, Jodieh Oliveira Santana Varejão, Isabela Penna Ceravolo, Victória Miranda Machado, Antoniana Ursine Krettli, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Felipe Terra Martins, Eduardo Jorge Pilau, Vinícius Ribeiro Montes, Markus Kohlhoff, Eduardo V. V. Varejão   +11 more
wiley   +1 more source

Cytotoxicity and trypanocidal activity of nifurtimox encapsulated in ethylcyanoacrylate nanoparticles

Biological Research, 2002
The aim of the present study was to study the trypanocidal activity of nanoparticles loaded with nifurtimox in comparison with the free drug against Trypanosoma cruzi, responsible for Chagas' disease.
GITTITH SÁNCHEZ, DANIELA CUELLAR, INES ZULANTAY, MARTA GAJARDO, GUILLERMO GONZÁLEZ-MARTIN   +4 more
doaj  

Enantiocomplementary Bioreduction of Flexible Ring N‐(3‐Oxobutyl)Heterocycles Providing Enantiopure Chiral Fragments for Drug Discovery

ChemBioChem, Volume 26, Issue 19, October 3, 2025.
Bioreduction of flexible ring N‐(3‐oxobutyl)‐heterocycles mediated by enantiocomplementary recombinant alcohol dehydrogenases [an (S)‐selective one from Rhodococcus aetherivorans (RaADH), and an (R)‐selective one from Lactobacillus kefir (LkADH)], as whole‐cell biocatalysts results in enantiopure (S)‐ and (R)‐alcohols (ee > 99%), which are promising ...
Máté Gergő Honvári, Levente András Mócza, Bence Attila Kucsinka, Pál Csuka, Viktória Bódai, Diana Maria Scrob, László Poppe, Gábor Hornyánszky   +7 more
wiley   +1 more source

Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières [PDF]

, 2009
BACKGROUND: Chagas disease (American trypanosomiasis) is a zoonotic or anthropozoonotic disease caused by the parasite Trypanosoma cruzi. Predominantly affecting populations in poor areas of Latin America, medical care for this neglected disease is often
Oliver Yun, M. Angeles Lima, Tom Ellman, Wilma Chambi, Sandra Castillo, Laurence Flevaud, Paul Roddy, Fernando Parreño, Pedro Albajar Viñas, Pedro Pablo Palma, Ricardo E. Gürtler, JHF Remme, R Tarleton, L Villa, P Roddy, AL de Andrade, S Sosa Estani, E Segura, M Zaidenberg, RE Gürtler, RE Gürtler, JR Coura, S Sosa-Estani, JP Chippaux, JR Coura, JR Cançado, CD Fernandes, ML Streiger, AG Schijman, S Sosa-Estani, AO Luquetti, F Guhl, S Sosa-Estani, G Guillén, GA Schmuñis, A Valencia   +35 more
core   +2 more sources

Mechanism of action of a nitroimidazole-thiadiazole derivate upon Trypanosoma cruzi tissue culture amastigotes

Memorias do Instituto Oswaldo Cruz, 1990
Megazol (CL 64,855) a very effective drug in experimental infections by Trypanosoma cruzi, and also in in vitro assays with vertebrate forms of the parasite, had its parasite, had its activity upon macromolecule biosynthesis tested using tissue culture ...
Solange L. de Castro, Maria de Nazareth L. Meirelles   +1 more
doaj   +1 more source

Phenotypic diversity and drug susceptibility of Trypanosoma cruzi TcV clinical isolates. [PDF]

PLoS ONE, 2018
Trypanosoma cruzi is a genetically heterogeneous group of organisms that cause Chagas disease. It has been long suspected that the clinical outcome of the disease and response to therapeutic agents are, at least in part, related to the genetic ...
Luz P Quebrada Palacio, Mariela N González, Yolanda Hernandez-Vasquez, Alina E Perrone, Adriana Parodi-Talice, Jacqueline Bua, Miriam Postan   +6 more
doaj   +1 more source