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Natural Products from Mexican Medicinal Plants as Promising Trypanocidal Drugs
ChemistrySelect, Volume 10, Issue 37, October 6, 2025.Chagas disease (American Trypanosomiasis) is caused by the protozoan Trypanosoma cruzi. Worldwide it is one of the seventeen neglected tropical diseases. There is a need of new drugs. This review assesses the literature (2012‐2024) of secondary metabolites isolated from Mexican plants active against this parasite.
Karla Daniela Rodríguez‐Hernández +2 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 1990 Single doses of drugs active aginst Trypanosoma cruzi (megazol, nifurtimox and benznidazole) induce a rapid clearence of the blood parasites in experimentally infected mice.
Eliane Lages-Silva +2 more
doaj +1 more source
Activation of bicyclic nitro-drugs by a novel nitroreductase (NTR2) in Leishmania [PDF]
, 2016 Drug discovery pipelines for the "neglected diseases" are now heavily populated with nitroheterocyclic compounds. Recently, the bicyclic nitro-compounds (R)-PA-824, DNDI-VL-2098 and delamanid have been identified as potential candidates for the treatment
Berriman, Matthew +7 more
core +4 more sources
PLoS Neglected Tropical Diseases, 2012 A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides.
Isabel M Vincent +5 more
doaj +1 more source
Doença de Chagas: Contribuições do Centro de Investigações Toxicológicas [PDF]
, 2015 La quimioterapia de la enfermedad de Chagas cuenta en la actualidad con el empleo de dos fármacos solamente: Nifurtimox y Benznidazol. Nifurtimox es un nitrofurano y Benznidazol es un compuesto nitroimidazólico. El uso de estas drogas para tratar la fase
Castro, Gerardo Daniel +3 more
core
Pregnancy, Volume 1, Issue 4, July 2025.Abstract Introduction Over 300,000 people living in the United States are estimated to have Chagas disease, a condition for which mother to child transmission may occur and early diagnosis is essential to reduce Chagas‐related morbidity and mortality. This study evaluated positive Trypanosoma cruzi (T. cruzi) screening serology among maternal donors of
Naseem Alavian +6 more
wiley +1 more source
Revista da Sociedade Brasileira de Medicina Tropical, 1989 Foram submetidos à quimioterapia com Nifurtimox (Bay 2502) ou com o Benzonidazol (Ro 7-1051) cinqüenta e oito camundongos cronicamente infectados com diferentes cepas do Trypanosoma cruzi (Tipos II e III) por períodos de 90 a 100 dias.
Sonia G. Andrade +2 more
doaj +3 more sources
Present situation and new strategies for Chagas disease chemotherapy: a proposal
Memorias do Instituto Oswaldo Cruz, 2009 Treatments for Chagas disease have been administered since the first attempts by Mayer & Rocha Lima (1912, 1914) and up to the drugs currently in use (nifurtimox and benznidazole), along with potential drugs such as allopurinol and first, second and ...
José Rodrigues Coura
doaj +1 more source
Tolerance and Safety of Nifurtimox in Patients with Chronic Chagas Disease [PDF]
, 2017 Background. Nifurtimox has been used to treat Chagas disease for 40 years, but tolerance and safety data in adults are scarce. We aimed to evaluate nifurtimox tolerance and safety in a cohort of Trypanosoma cruzi-infected adult patients in a country of ...
Alirol, Emilie +5 more
core
Availability and affordability of treatment for Human African Trypanosomiasis. [PDF]
, 2001 Human African Trypanosomiasis (HAT) is a re-emerging disease whose usual treatments are becoming less efficient because of the increasing parasite resistance.
Etchegorry, M +4 more
core +3 more sources