Results 81 to 90 of about 7,787 (204)

Present situation and new strategies for Chagas disease chemotherapy: a proposal

Memorias do Instituto Oswaldo Cruz, 2009
Treatments for Chagas disease have been administered since the first attempts by Mayer & Rocha Lima (1912, 1914) and up to the drugs currently in use (nifurtimox and benznidazole), along with potential drugs such as allopurinol and first, second and ...
José Rodrigues Coura
doaj   +1 more source

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
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Adverse events associated with benznidazole treatment for Chagas disease in children and adults

British Journal of Clinical Pharmacology, Volume 90, Issue 12, Page 3334-3347, December 2024.
Aims Chagas disease (ChD) affects approximately 7 million people in Latin America, with benznidazole being the most commonly used treatment. Methods Data from a retrospective cohort study in Argentina, covering January 1980 to July 2019, was reanalysed to identify and characterize benznidazole‐related adverse drug reactions (ADRs).
Cintia Valeria Cruz, Andres Rabinovich, Guillermo Moscatelli, Samanta Moroni, Nicolas González, Facundo Garcia‐Bournissen, Griselda Ballering, Hector Freilij, Jaime Altcheh   +8 more
wiley   +1 more source

Etiological drug treatment of human infection by Trypanosoma cruzi Tratamento etiológico por droga da infecção humana pelo Trypanosoma cruzi

Revista do Instituto de Medicina Tropical de São Paulo, 1996
Forty-nine American Trypanosomiasis (Chagas' disease) patients, with xenodiagnosis proven parasitemia were treated by the authors. Forty-one of these patients were given benznidazole, at dosages ranging from 5mg/kg/day to 8mg/kg/day, during a pre ...
Guido Carlos Levi, Isa Maria Fraga Lobo, Esper Georges Kallás, Vicente Amato Neto   +3 more
doaj   +1 more source

Exploring Quinazoline Nitro-Derivatives as Potential Antichagasic Agents: Synthesis and In Vitro Evaluation

Molecules
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease in humans. The current antichagasic drugs nifurtimox and benznidazole have inconveniences of toxicity; therefore, the search for alternative therapeutic strategies is necessary.
Citlali Vázquez, Audifás-Salvador Matus-Meza, Oswaldo Nuñez-Moreno, Brenda Michelle Barbosa-Sánchez, Victor Manuel Farías-Gutiérrez, Mariana Mendoza-Conde, Francisco Hernández-Luis, Emma Saavedra   +7 more
doaj   +1 more source

Lymphocyte Transformation Test (LTT) in Allergy to Benznidazole: A Promising Approach

Frontiers in Pharmacology, 2019
Benznidazole (Bzn) from the nitroimidazole family and nifurtimox from nitrofurans family, are drugs used as first and second line treatment for acute and chronic phases of Chagas disease (CD). Even though skin reactions are frequent, confirmed allergy to
M. Andreína Marques-Mejías, Rosario Cabañas, Rosario Cabañas, Rosario Cabañas, Elena Ramírez, Elena Ramírez, Javier Domínguez-Ortega, Javier Domínguez-Ortega, Ana Fiandor, Ana Fiandor, Elena Trigo, Elena Trigo, Santiago Quirce, Santiago Quirce, Teresa Bellón, Teresa Bellón   +15 more
doaj   +1 more source

Kinetoplastids:related protozoan pathogens, different diseases [PDF]

, 2008
Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their
Agranoff, Alan Fairlamb, Albrecht, Ambroise-Thomas, Andrade, Armijos, Atwood, Avila, Balana-Fouce, Benchimol Barbosa, Bern, Berriman, Bhattacharya, Bhattacharya, Bisser, Brun, Burleigh, Burns, Burri, Campos-Neto, Castro, Chava, Cohen, Coler, Coler, Coler, Combs, Croft, da Costa, de Castro, De Luca, de Macedo, Deborggraeve, Deng, Denkers, Dias, Doyle, Eastman, El Kouni, El-Sayed, Engel, Engers, Enserink, Ferguson, Frearson, Genaro, Ghalib, Ghalib, Gorczynski, Grazia, Grevelink, Guler, Gurtler, Gurtler, Gurtler, Gürtler, Hammarton, Hawn, Heby, Hopkins, Houghton, Jim McKerrow, Jones, Ken Stuart, Kgori, Khalil, Khalil, Krauth-Siegel, Kroeger, Kropf, Launois, Lee, Lejon, Lohoff, Magnus, Marsden, Marth, Martin, Mayrink, Mazurek, McConville, Molina, Nare, Nwaka, Nylen, Olliaro, Opperdoes, Ouellette, Panethymitaki, Picollo, Pirard, Radwanska, Radwanska, Ramesh, Reed, Reed, Reiner, Reithinger, Reithinger, Renslo, Reto Brun, Ricardo E. Gürtler, Rick Tarleton, Sadeghian, Scharton-Kersten, Schmid, Schnaufer, Simon Croft, Skeiky, Sosa, Soto, Steve Reed, Stuart, Sundar, Sundar, Tarleton, Tarleton, Tarleton, Thakur, Torr, Urbina, Viotti, Viotti, Welburn, Werbovetz, Xong, Young, Zijlstra   +127 more
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Sustainable Multi-Target Drugs for Neglected Tropical Diseases Caused by Trypanosomatids: Dream or Reality?

Proceedings, 2017
The development of nifurtimox-eflornithine combination therapy (NECT) has been a major and emboldening advance towards more effective and simple medications in the field of neglected tropical diseases (NTD) caused by Trypanosomatids. [...]
Maria Laura Bolognesi
doaj   +1 more source

Medicinal Plants of Chile: Evaluation of their Anti-Trypanosoma cruzi Activity [PDF]

, 2013
San Martin, J (San Martin, Jose). Univ Talca, Inst Biol Vegetal & Biotecnol, Talca, ChileThe extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity.
Christen, P., Ferreira, J., Kemmerling, U., Lopez-Munoz, R., Maya, J.D., Morello, A., Munoz, O.M., San Martin, J.   +7 more
core   +2 more sources

The genetics and genomics of Trypanosoma cruzi [PDF]

, 2007
Trypanosoma cruzi is a kinetoplastid parasite that causes Chagas disease. Trypanosomes are unusual organisms in many aspects of its genetics and molecular and cellular biology and considered a paradigm of the exception of the rule in the eukaryotic ...
Vazquez, Martin Pablo
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