Results 11 to 20 of about 504 (145)

An exploration of the genetics of the mutant Huntingtin (mHtt) gene in a cohort of patients with chorea from different ethnic groups in sub‐Saharan Africa [PDF]

Annals of Human Genetics, Volume 89, Issue 4, Page 149-157, July 2025.
Abstract Background Africans are underrepresented in Huntington's disease (HD) research. A European ancestor was postulated to have introduced the mutant Huntingtin (mHtt) gene to the continent; however, recent work has shown the existence of a unique Htt haplotype in South‐Africa specific to indigenous Africans.
Mendi J Muthinja, Carlos Othon Guelngar, Maouly Fall, Fatumah Jama, Huda Aldeen Shuja, Jamila Nambafu, Daniel Gams Massi, Oluwadamilola O. Ojo, Njideka U. Okubadejo, Funmilola Tolulope Taiwo, Alassane Mamadou Diop, Coudjou J. D. G. de Chacus, Fodé Abass Cissé, Amara Cissé, Juzar Hooker, Dilraj Sokhi, Henry Houlden, Mie Rizig   +17 more
wiley   +2 more sources

Epilepsy in CHAD: Realities, constraints, and prospects [PDF]

Epilepsia Open, Volume 9, Issue 6, Page 2049-2054, December 2024.
Abstract Epilepsy is a significant public health problem. More than 50 million people worldwide live with epilepsy, and over three‐quarters of them are in low‐ and middle‐income countries. The situation in Chad regarding people with epilepsy is challenging to assess, starting from the shortage of scientific data, the inadequacy of technical facilities,
Foksouna Sakadi, Madjirabe Ngardidjim Christian, Toure Mohamed Lamine, Kamis Dakisia, Nderbe Melom Christelle, Diponbe Doufene, Lintel Anicet Foksia, Carlos Othon Nguelngar, Anatole Balanmo, Kobada Babing‐ne, Desire Nalire, Cisse Amara   +11 more
wiley   +2 more sources

Scaling Laws in Language Families [PDF]

Entropy
This article investigates scaling laws within language families using data from over six thousand languages and analyzes emergent patterns observed in Zipf-like classification graphs.
Maelyson Rolim Fonseca dos Santos, Marcelo Andrade de Filgueiras Gomes   +1 more
doaj   +2 more sources

Characterization of CYP2D6 Pharmacogenetic Variation in Sub‐Saharan African Populations [PDF]

Clinical Pharmacology &Therapeutics, Volume 113, Issue 3, Page 643-659, March 2023., 2023
Cytochrome P450 2D6 (CYP2D6) is a key enzyme in drug response owing to its involvement in the metabolism of ~ 25% of clinically prescribed medications. The encoding CYP2D6 gene is highly polymorphic, and many pharmacogenetics studies have been performed worldwide to investigate the distribution of CYP2D6 star alleles (haplotypes); however, African ...
David Twesigomwe, Britt I. Drögemöller, Galen E.B. Wright, Clement Adebamowo, Godfred Agongo, Palwendé R. Boua, Mogomotsi Matshaba, Maria Paximadis, Michèle Ramsay, Gustave Simo, Martin C. Simuunza, Caroline T. Tiemessen, Zané Lombard, Scott Hazelhurst   +13 more
wiley   +2 more sources

Mauriac Syndrome in Sudanese Children: An Old Syndrome Still Existing in Resource‐Limited Countries [PDF]

Pediatric Diabetes, Volume 2025, Issue 1, 2025.
Objective: Mauriac syndrome (MS) is a rare condition linked to inadequate glycemic control in type 1 diabetes mellitus (T1DM) and has also rarely been reported in patients with neonatal diabetes. MS manifests as growth failure, delayed puberty, cushingoid features, and hepatomegaly.
Mariam M. Ismail, Olivia A. Al-Hassan, Ghassan Mohamadsalih, Mohamed A. Abdullah, Ben Wheeler   +4 more
wiley   +2 more sources

Epidemiologic study on prostate cancer in Sudanese men across African ethnic groups [PDF]

Scientific Reports
This study sought to investigate the demographic and clinical characteristics of Sudanese men diagnosed with prostate cancer (PCa) to highlight differences in diagnosis among the three major ethnolinguistic groups.
Dalia Ahmed, Elsadig Ahmed Adam Mohammed, Mohamed Elimam Mohamed Ahmed, Yassin Mohamed Osman Abdalla, Ibrahin Hadad, Alsmawal Awad Elimam, Yousif Abdelhameed Mohammed, Moawia Mohammed Ali Elhassan, Amar Mohamed Ismail, Asim Osman Abdoun, Stefano Cacciatore, Luiz Fernando Zerbini   +11 more
doaj   +2 more sources

Disease‐Modifying Trials in Treated Parkinson's Disease: “Stable Treated” Does Not Equate with Biological Stability [PDF]

Movement Disorders, Volume 40, Issue 9, Page 1778-1790, September 2025.
Abstract Traditionally, clinical trials of putative disease‐modifying therapies in Parkinson's disease have enrolled untreated patients at the earliest clinical stages of their disease. Due to a number of challenges inherent with this approach, there has been a recent move to a different study design, enrolling patients who are already taking “stable ...
M. Maral Mouradian, A. Jon Stoessl, Anthony E. Lang   +2 more
wiley   +2 more sources

Pastoralism, hunting, and coexistence: Domesticated and wild bovids in Neolithic Sudan

International Journal of Osteoarchaeology, Volume 33, Issue 3, Page 517-531, May/June 2023., 2023
Abstract The interactions between mobile pastoralists and semi‐sedentary Nilotic foraging groups in the Middle Nile Valley had long‐term implications for the development of social complexity as seen in the ancient African kingdom of Kerma. This study presents the results of the zooarcheological analysis of animal remains from two sites in the 4th ...
Shayla Monroe, Stuart Tyson Smith, Sarah B. McClure   +2 more
wiley   +1 more source

Second person agreement allomorphy in Masarak

Studies in African Linguistics, 2013
Masarak (also known as Masalit, sometimes spelled Massaleit), an endangered Nilo-Saharan language spoken in Darfur, is characterized by complex agreement patterns, particularly in the second person. This article outlines Masarak agreement patterns in the
Ruth Brillman
doaj   +3 more sources

Nominal and verbal number in Bilugu Opo

Studies in African Linguistics, 2019
Opo (a.k.a. Opuuo, Tʼapo [lgn]), a Koman language spoken in Ethiopia and South Sudan, has complex and interesting systems of both NOMINAL NUMBER and VERBAL NUMBER.
Joshua A.G. Smolders
doaj   +3 more sources