Results 11 to 20 of about 278 (112)

An exploration of the genetics of the mutant Huntingtin (mHtt) gene in a cohort of patients with chorea from different ethnic groups in sub-Saharan Africa. [PDF]

Ann Hum Genet
Abstract Background Africans are underrepresented in Huntington's disease (HD) research. A European ancestor was postulated to have introduced the mutant Huntingtin (mHtt) gene to the continent; however, recent work has shown the existence of a unique Htt haplotype in South‐Africa specific to indigenous Africans.
Muthinja MJ, Guelngar CO, Fall M, Jama F, Shuja HA, Nambafu J, Massi DG, Ojo OO, Okubadejo NU, Taiwo FT, Diop AM, de Chacus CJDG, Cissé FA, Cissé A, Hooker J, Sokhi D, Houlden H, Rizig M.   +17 more
europepmc   +2 more sources

Epilepsy in CHAD: Realities, constraints, and prospects. [PDF]

Epilepsia Open
Abstract Epilepsy is a significant public health problem. More than 50 million people worldwide live with epilepsy, and over three‐quarters of them are in low‐ and middle‐income countries. The situation in Chad regarding people with epilepsy is challenging to assess, starting from the shortage of scientific data, the inadequacy of technical facilities,
Sakadi F, Christian MN, Lamine TM, Dakisia K, Christelle NM, Doufene D, Foksia LA, Nguelngar CO, Balanmo A, Babing-Ne K, Nalire D, Amara C.   +11 more
europepmc   +2 more sources

Characterization of CYP2D6 Pharmacogenetic Variation in Sub-Saharan African Populations. [PDF]

Clin Pharmacol Ther, 2023
Cytochrome P450 2D6 (CYP2D6) is a key enzyme in drug response owing to its involvement in the metabolism of ~ 25% of clinically prescribed medications. The encoding CYP2D6 gene is highly polymorphic, and many pharmacogenetics studies have been performed worldwide to investigate the distribution of CYP2D6 star alleles (haplotypes); however, African ...
Twesigomwe D, Drögemöller BI, Wright GEB, Adebamowo C, Agongo G, Boua PR, Matshaba M, Paximadis M, Ramsay M, Simo G, Simuunza MC, Tiemessen CT, Lombard Z, Hazelhurst S.   +13 more
europepmc   +2 more sources

Evidence for Pathogen-Driven Selection Acting on HLA-DPB1 in Response to Plasmodium falciparum Malaria in West Africa. [PDF]

Ecol Evol
This study analyzed HLA class II genes in over 1,000 individuals from 23 African populations, revealing genetic diversity influenced by geography, culture, and environment, with a significant link between Plasmodium falciparum prevalence and variation at the DPB1 gene.
Goeury T, Faye N, Gerbault P, Černý V, Crubézy E, Chiaroni J, Brouk H, Brunet L, Galan M, de Groot NG, Nunes JM, Sanchez-Mazas A.   +11 more
europepmc   +2 more sources

Gender variation across the Oromo dialects: A corpus‐based study*

Studia Linguistica, Volume 77, Issue 3, Page 453-495, December 2023., 2023
Abstract This study aims to (1) demonstrate the position of the Oromo gender system in Corbett's (1991) typology of gender; (2) illustrate major syntactic gender variation across the Oromo dialects; (3) identify factors that contributed to the gender variation, and (4) illustrate the morphosyntax of the Oromo gender system.
Tekabe Legesse Feleke, Terje Lohndal
wiley   +1 more source

Experiential motivation and the linguistics of sitting, standing, and lying

WIREs Cognitive Science, Volume 13, Issue 4, July/August 2022., 2022
Sit, Stand, and Lie (2004): A set of three sculptures designed and created by Frances O. Cuyler (Edmonton, Canada). Abstract The three human at‐rest postures of sitting, standing, and lying are basic, recurring features of human behavior and may reasonably be called primary postures.
John Newman
wiley   +1 more source

Genetic landscape of Gullah African Americans

American Journal of Physical Anthropology, Volume 175, Issue 4, Page 905-919, August 2021., 2021
Abstract Objectives Gullah African Americans are descendants of formerly enslaved Africans living in the Sea Islands along the coast of the southeastern U.S., from North Carolina to Florida. Their relatively high numbers and geographic isolation were conducive to the development and preservation of a unique culture that retains deep African features ...
Kip D. Zimmerman, Theodore G. Schurr, Wei‐Min Chen, Uma Nayak, Josyf C. Mychaleckyj, Queen Quet, Lee H. Moultrie, Jasmin Divers, Keith L. Keene, Diane L. Kamen, Gary S. Gilkeson, Kelly J. Hunt, Ida J. Spruill, Jyotika K. Fernandes, Melinda C. Aldrich, David Reich, W. Timothy Garvey, Carl D. Langefeld, Michèle M. Sale, Paula S. Ramos   +19 more
wiley   +1 more source

Zamucoan Person Marking as a Perturbed System*

Studia Linguistica, Volume 75, Issue 2, Page 265-288, August 2021., 2021
Abstract This paper analyzes the Zamucoan system of Person markers: personal pronouns, verbal and possessive inflection. Comparing the three documented languages (Ayoreo and Chamacoco, currently spoken, and extinct Old Zamuco), one can reconstruct for a very ancient stage of this language family an agglutinating structure for both personal pronouns and
Pier Marco Bertinetto
wiley   +1 more source

Nilo-Saharan Languages: Resources for language policy and planning

, 2021
A presentation at the 2021 Nilo-Saharan Linguistics Colloquium, hosted by the University of Edinburgh.
openaire   +2 more sources

Subject Clitics: New Evidence from Old Nubian

Glossa, 2018
This article treats a set of subject cross-referencing morphemes in the medieval Nilo-Saharan language Old Nubian, traditionally called “personal endings.” Based on an analysis of their syntactic distribution and morphology, I argue that this set can be ...
Vincent W.J. van Gerven Oei
doaj   +2 more sources