Main Pro-Apoptotic Member of BCL-2 Family Proteins-BAX [PDF]
, 2010 Programmed cell death (apoptosis) plays a vital role in the regulation of cellular homeostasis. Because of apoptosis fundamental importance, this process is highly regulated.
Kiliańska, Zofia, Żolnierczyk, Jolanta
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Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease [PDF]
, 2007 Gene expression profiling is a powerful method by which alterations in gene expression can be interrogated in a single experiment. The disease familial adenomatous polyposis (FAP) is associated with germline mutations in the APC gene, which result in ...
Nikola A Bowden +2 more
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Integrated transcriptomics establish macrophage polarization signatures and have potential applications for clinical health and disease [PDF]
, 2015 Growing evidence defines macrophages (Mφ) as plastic cells with wide-ranging states of activation and expression of different markers that are time and location dependent.
Barbé-Tuana, Florencia M. +8 more
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Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function [PDF]
, 2021 Deficiency of the serine hydrolase prolyl endopeptidase-like (PREPL) causes a recessive metabolic disorder characterized by neonatal hypotonia, feeding difficulties, and growth hormone deficiency.
et al, +2 more
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Role of mitochondrial heat-shock proteins and immunophilins in neurodegenerative diseases [PDF]
, 2021 Pathophysiologic conditions of neurodegenerative diseases are unquestionably related to protein misfolding. The accumulation of misfolded proteins into relatively ordered structures such as fibrillar intracellular and extracellular amyloids results in ...
Ciucci, Sol Micaela +3 more
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Small molecules targeting Pin1 as potent anticancer drugs [PDF]
, 2023 Background: Pin1 is a member of the evolutionarily conserved peptidyl-prolyl isomerase (PPIase) family of proteins. Following phosphorylation, Pin1-catalyzed prolyl-isomerization induces conformational changes, which serve to regulate the function of ...
Jing Zhang +8 more
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Cinobufacini Injection Inhibits the Proliferation of Triple-Negative Breast Cancer Through the Pin1-TAZ Signaling Pathway [PDF]
, 2022 Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC), which is characterized by the total absence of human epidermal growth factor receptor 2 (HER2), progesterone receptor (PR), and estrogen receptor (ER) expression ...
Chen, Yuru +10 more
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Cancer Management and Research, 2020 Su Wan,1 Guantai Ni,1 Jin Ding,1 Yuansheng Huang2 1Department of Obstetrics and Gynecology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, People’s Republic of China; 2Department of Orthopedics, Yijishan Hospital of Wannan Medical
Wan S, Ni G, Ding J, Huang Y
doaj
Circadian and light-driven regulation of rod dark adaptation [PDF]
, 2015 Continuous visual perception and the dark adaptation of vertebrate photoreceptors after bright light exposure require recycling of their visual chromophore through a series of reactions in the retinal pigmented epithelium (RPE visual cycle). Light-driven
Corbo, Joseph C +3 more
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Biomarker discovery for asthma phenotyping: From gene expression to the clinic [PDF]
, 2016 Asthma is considered a complex respiratory disease of which various asthma phenotypes are being discovered. Clinical biomarkers have shown to be successful in the management of asthma phenotypes.
Wagener, A.H.
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