Results 11 to 20 of about 827 (92)

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

MYC and therapy resistance in cancer: risks and opportunities

Molecular Oncology, Volume 16, Issue 21, Page 3828-3854, November 2022., 2022
Therapy resistance is a major limitation in clinical oncology. The MYC oncogene not only drives cancer progression, but also favors resistance to classical chemotherapy and targeted therapies. This review summarizes the clinical evidence and molecular mechanisms linking MYC and therapy resistance, and discusses possible innovative strategies to target ...
Giulio Donati, Bruno Amati
wiley   +1 more source

ISGylation of EMD promotes its interaction with PDHA to inhibit aerobic oxidation in lung adenocarcinoma

Journal of Cellular and Molecular Medicine, Volume 26, Issue 19, Page 5078-5094, October 2022., 2022
Abstract Abnormal nuclear structure caused by dysregulation of skeletal proteins is a common phenomenon in tumour cells. However, how skeletal proteins promote tumorigenesis remains uncovered. Here, we revealed the mechanism by which skeletal protein Emerin (EMD) promoted glucose metabolism to induce lung adenocarcinoma (LUAD).
Congcong Zhang, Jiangtao Cui, Leiqun Cao, Xiaoting Tian, Yayou Miao, Yikun Wang, Shiyu Qiu, Wanxin Guo, Lifang Ma, Jinjing Xia, Xiao Zhang   +10 more
wiley   +1 more source

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Oxidative stress involves enormously in the development of chronic inflammatory bone disease, wherein the overproduction of reactive oxygen species (ROS) negatively impacts the bone remodeling via promoting osteoclastogenesis and inhibiting osteogenesis. Lacking effective therapies highlights the importance of finding novel treatments.
Zichen Cui, Changgong Feng, Jiazheng Chen, Yi Wang, Qi Meng, Shihao Zhao, Yuanji Zhang, Dianjie Feng, Ziqing Li, Shui Sun, Yuetao Zhao   +10 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

British Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +32 more
wiley   +1 more source

Single human oocyte transcriptome analysis reveals distinct maturation stage‐dependent pathways impacted by age

Aging Cell, Volume 20, Issue 5, May 2021., 2021
Here we used single‐oocyte RNA‐Seq to study the transcriptome changes occurring during human oocyte aging. We sampled Germinal Vesicle (GV) stage oocytes from women of age 18–43 and analyzed them directly (GV) or after in vitro maturation (IVM‐MII). We observed that age has a bigger impact on the IVM‐MII transcriptome.
Sílvia Llonch, Montserrat Barragán, Paula Nieto, Anna Mallol, Marc Elosua‐Bayes, Patricia Lorden, Sara Ruiz, Filippo Zambelli, Holger Heyn, Rita Vassena, Bernhard Payer   +10 more
wiley   +1 more source

PIN1P1 is activated by CREB1 and promotes gastric cancer progression via interacting with YBX1 and upregulating PIN1. [PDF]

J Cell Mol Med
Abstract Long noncoding RNAs (lncRNAs) play critical roles in the carcinogenesis and progression of cancers. However, the role and mechanism of the pseudogene lncRNA PIN1P1 in gastric carcinoma remain unclear. The expression and effects of lncRNA PIN1P1 in gastric cancer were investigated.
Wang YW, Zhu WJ, Ma RR, Tian YR, Chen X, Gao P.   +5 more
europepmc   +2 more sources

Intramolecular interaction of B‐MYB is regulated through Ser‐577 phosphorylation

FEBS Letters, Volume 594, Issue 24, Page 4266-4279, December 2020., 2020
The transcription factor B‐MYB is an important regulator of cell cycle‐related processes that is activated by step‐wise phosphorylation of multiple sites by cyclin‐dependent kinases (CDKs) and conformational changes induced by the peptidylprolyl cis/trans isomerase Pin1.
Eugen Werwein, Abhiruchi Biyanee, Karl‐Heinz Klempnauer   +2 more
wiley   +1 more source

Peptidylprolylisomerases, Protein Folders, or Scaffolders? The Example of FKBP51 and FKBP52

BioEssays, Volume 42, Issue 7, July 2020., 2020
Peptidylprolylisomerases (PPIases) expedite the transition between two conformational states of proteins. It is hypothesized that this feature of PPIases is a side effect of the actual function of PPIases, which is the promotion of interactions of other proteins through scaffolding.
Theo Rein
wiley   +1 more source