Results 41 to 50 of about 80,438 (295)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Preparation and Certification of Niobium-Tantalum Concentrate Reference Materials

open access: yesYankuang ceshi, 2018
BACKGROUND Niobium-tantalum concentrate reference materials play an important role in monitoring mineral smelting and sample analysis. There is a great demand of niobium-tantalum concentrate reference materials in the dressing plant and metallurgical ...
ZHAO Xiao-liang   +5 more
doaj   +1 more source

Plasma Processing of Large Curved Surfaces for SRF Cavity Modification [PDF]

open access: yes, 2014
Plasma based surface modification of niobium is a promising alternative to wet etching of superconducting radio frequency (SRF) cavities. The development of the technology based on Cl2/Ar plasma etching has to address several crucial parameters which ...
Im, Do   +5 more
core   +4 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Influence of Niobium on the Beginning of the Plastic Flow of Material during Cold Deformation

open access: yesThe Scientific World Journal, 2013
Investigations were conducted on low-carbon steel and the steel with same chemical composition with addition of microalloying element niobium. While tensile testing was carried out, the thermographic measurement was tacking place simultaneously.
Stoja Rešković, Ivan Jandrlić
doaj   +1 more source

Influence of Nickel on Niobium Nitride Formation in As-Cast Stainless Steels

open access: yesMetals, 2022
The influence of the nickel content and cooling rate on niobium nitride precipitation in as-cast stainless steels were analysed. Niobium microalloying is important for mechanical properties and the prevention of intergranular corrosion in stainless ...
Anže Bajželj   +3 more
doaj   +1 more source

SRF Cavity Fabrication and Materials

open access: yes, 2015
The technological and metallurgical requirements of material for highgradient superconducting cavities are described. High-purity niobium, as the preferred metal for the fabrication of superconducting accelerating cavities, should meet exact ...
Singer, W
core   +1 more source

Measurement of Gravitomagnetic and Acceleration Fields Around Rotating Superconductors [PDF]

open access: yes, 2006
It is well known that a rotating superconductor produces a magnetic field proportional to its angular velocity. The authors conjectured earlier, that in addition to this so-called London moment, also a large gravitomagnetic field should appear to explain
Marhold, K.   +3 more
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Corrosion behaviour of sintered Ti–Ni–Cu–Nb in 0.9% NaCl environment

open access: yesJournal of Materials Research and Technology, 2015
The uniform and localized corrosion behaviour of sintered Ti–Ni containing niobium and copper additions were studied using potentiodynamic and cyclic polarization measurements in 0.9% sodium chloride.
Moipone Linda Lethabane   +2 more
doaj   +1 more source

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