Results 71 to 80 of about 10,481 (199)
Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe +2 more
wiley +1 more source
Nipah Virus: A Multidimensional Update
Nipah virus (NiV) is an emerging zoonotic paramyxovirus to which is attributed numerous high mortality outbreaks in South and South-East Asia; Bangladesh’s Nipah belt accounts for the vast majority of human outbreaks, reporting regular viral emergency events.
Javier Faus-Cotino +2 more
openaire +4 more sources
Abstract: Nipah virus caused outbreaks in Malaysia and Singapore in 2009 with a high mortality rates. It also erupted in Bangladesh, India, and the Philippines. Nipah virus infection varies from asymptomatic to severe manifestation with a mortality rate varies from 38% to 80%.
openaire +3 more sources
ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou +8 more
wiley +1 more source
A general framework for modeling pathogen transmission in co‐roosting host communities
Abstract Cross‐species transmission of pathogens can be facilitated by frequent contact among wildlife. Cross‐species transmission is often driven by phylogenetic similarity between host species, but the role this plays when multiple host species co‐roost is unknown.
Molly C. Simonis, Daniel J. Becker
wiley +1 more source
Nipah virus, a zoonotic pathogen, can cause debilitating disease and death in humans. Currently, countermeasures are limited, with several in various stages of testing but none yet FDA-approved for human use.
Sara C Johnston +19 more
doaj +1 more source
Background The recent emergence of four new members of the paramyxovirus family has heightened the awareness of and re-energized research on new and emerging diseases.
Eaton Bryan T +5 more
doaj +1 more source
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
Supaporn Wacharapluesadee +9 more
openaire +3 more sources
Structural Insights Into the Nuclear Import of Gallid Alphaherpesvirus 1 Large Tegument Protein
The study identifies and characterizes a bipartite nuclear localization signal within the GaAHV‐1 UL36 large tegument protein, revealing its structural interaction with importin α/β1 and confirming a conserved mechanism of nuclear import through biochemical, crystallographic, and mutational analyses.
Babu Kanti Nath +7 more
wiley +1 more source
Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods
This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu +5 more
wiley +1 more source

