Omicron SARS-CoV-2 infection management and outcomes in patients with hematologic disease and recipients of cell therapy [PDF]
Introduction: Scarce real-life data exists for COVID-19 management in hematologic disease (HD) patients in the Omicron era. Purpose: To assess the current clinical management and outcome of SARS-CoV-2 infection diagnosed, identify the risk factors for ...
Aiello, Tommaso Francesco +30 more
core +1 more source
Sequential or Combination Treatments as Rescue Therapies in Immunocompromised Patients with Persistent SARS-CoV-2 Infection in the Omicron Era: A Case Series [PDF]
Bonora, Stefano +7 more
core +1 more source
Objective: Calculate rates of nirmatrelvir-ritonavir prescription and assess area-level social deprivation as an effect modifier of patient characteristics on nirmatrelvir-ritonavir for the treatment of COVID-19.
Esther E. Velásquez +5 more
doaj +1 more source
Background: According to the Evaluation of Protease Inhibition for COVID-19 in High-Risk Patients (EPIC-HR) study, compared with a placebo, nirmatrelvir/ritonavir significantly reduced the risk of coronavirus disease 2019 (COVID-19)-related ...
Chienhsiu Huang, Sufang Kuo, Lichen Lin
doaj +1 more source
SARS-CoV-2 genomic evolution during a severe and long-lasting omicron infection under antiviral therapy [PDF]
BackgroundProlonged SARS-CoV-2 infection observed in immunocompromised individuals even in the presence of antiviral treatment provides opportunities for viruses to evolve in immune escape and drug-resistant variants.Case presentationA 72-year-old male ...
Alagna, Laura +10 more
core +1 more source
Background Two oral antivirals for treatment of COVID-19 are available in Australia, nirmatrelvir-ritonavir, which is recommended, and molnupiravir, which is approved for use when nirmatrelvir-ritonavir is contraindicated.
Laura J. Edwards +6 more
doaj +1 more source
ORCHESTRA Delphi consensus: diagnostic and therapeutic management of SARS-CoV-2 infection in solid organ transplant recipients [PDF]
Objectives: We aimed to address existing knowledge gaps regarding risk stratification, best use of diagnostic resources, optimal treatment, and general management of SARS-CoV-2 infection in solid organ transplant (SOT) recipients.
Tazza, Beatrice +14 more
core +2 more sources
Successful use of nirmatrelvir/ritonavir in immunocompromised patients with persistent and/or relapsing COVID-19 [PDF]
Bartoloni, Alessandro +14 more
core +1 more source
Clinical Effectiveness of Ritonavir-Boosted Nirmatrelvir—A Literature Review
Nirmatrelvir/Ritonavir is an oral treatment for mild to moderate COVID-19 cases with a high risk for a severe course of the disease. For this paper, a comprehensive literature review was performed, leading to a summary of currently available data on ...
Sydney Paltra, Tim O. F. Conrad
doaj +1 more source
ORCHESTRA Delphi consensus: clinical management of SARS-CoV-2 infection in people with HIV [PDF]
Objectives: The interaction between HIV and COVID-19 resulted in a syndemic that showed an excess burden of disease for people with HIV (PWH). Four years of the COVID-19 pandemic have raised many unsolved questions about the optimal care of COVID-19 in ...
Alemán-Rodríguez, Aurora +81 more
core +1 more source

