Prevalence of potentially inappropriate use of antiviral therapy with simnotrelvir-ritonavir versus nirmatrelvir-ritonavir in hospitalised patients: a retrospective study in Beijing, China [PDF]
BMJ Open Respiratory ResearchBackground While simnotrelvir-ritonavir and nirmatrelvir-ritonavir, the oral antiviral agents targeting the 3C-like proteases, are widely used in China, robust data on their appropriate use remain limited in hospitalised patients.
Hui Zhang +9 more
doaj +2 more sources
A case report of drug–drug interaction between voriconazole and simnotrelvir/ritonavir [PDF]
Frontiers in AntibioticsCo-administration of simnotrelvir/ritonavir with voriconazole should be avoided, as stated in the product insert of simnotrelvir/ritonavir, due to the anticipated decrease in the plasma concentration of voriconazole.
Tingting Chen, Qingquan Zhang
doaj +2 more sources
Infectious Diseases and TherapyIntroduction Limited data exist regarding real-world utilization of nirmatrelvir/ritonavir. We identified predictors of nirmatrelvir/ritonavir use among Veterans Affairs (VA) outpatients nationally. Methods We conducted a retrospective cohort study among
, Vrishali V Lopes, Laura Puzniak
exaly +2 more sources
Severe HCoV‐OC43 Pneumonia in a 25‐Year‐Old Woman Following Allogeneic Hematopoietic Stem Cell Transplantation [PDF]
The Clinical Respiratory JournalBackground We report the case of a 25‐year‐old woman with a history of acute lymphoblastic leukemia who developed progressive dyspnea and fever following allogeneic hematopoietic stem cell transplantation.
Mingzhou Zhang +5 more
doaj +2 more sources
Senescence as a main mechanism of Ritonavir and Ritonavir‐NO action against melanoma [PDF]
Molecular Carcinogenesis, 2019 AbstractThe main focus of this study is exploring the effect and mechanism of two HIV‐protease inhibitors: Ritonavir and Ritonavir‐nitric oxide (Ritonavir‐NO) on in vitro growth of melanoma cell lines. NO modification significantly improved the antitumor potential of Ritonavir, as the IC50 values of Ritonavir‐NO were approximately two times lower than ...
Svetlana Paskaš +2 more
exaly +7 more sources
Mild self-declared side effects of boosted darunavir associated with other antiretrovirals in Romanian HIV-1 infected patients [PDF]
Archives of the Balkan Medical Union, 2021 Introduction. Antiretroviral therapy (ART) is used in human immunodeficiency virus (HIV)-infected patients, to suppress viral replication and slow disease progression.
Ruxandra C. MARIN +2 more
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Pharmacoepidemiological research of COVID-19 in the Russian Federation EGIDA-2020
Терапевтический архив, 2021 Aim. An analysis of coronavirus infection in Russia and evaluation of different AVT regimens effectiveness. Materials and methods. The study involved a retrospective analysis of 1082 patient records with laboratory-confirmed COVID-19 in 17 regions of ...
Natalia Yu. Pshenichnaya +17 more
doaj +1 more source
Infectious Disease Reports, 2023 Vaccines remain the cornerstone of medical prevention and are highly effective in reducing the risk of severe disease and death due to coronavirus disease 2019 (COVID-19).
Ioannis Karniadakis +5 more
doaj +1 more source
Discovery of alliin as a putative inhibitor of the main protease of SARS-CoV-2 by molecular docking
BioTechniques, 2020 The outbreak of viral pneumonia caused by the novel coronavirus SARS-CoV-2 that began in December 2019 caused high mortality. It has been suggested that the main protease (Mpro) of SARS-CoV-2 may be an important target to discover pharmaceutical ...
Bijun Cheng, Tianjiao Li
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Pharmaceuticals, 2022 The formulation of poorly water-soluble drugs is one of the main challenges in the pharmaceutical industry, especially in the development of oral dosage forms.
Arif Budiman, Diah Lia Aulifa
doaj +1 more source